Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field

Individuals with 22q11 deletion syndrome (22q11DS; DiGeorge/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defects. Most individuals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions. The T-box transcription factor TBX1 , lies within th...

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Veröffentlicht in:	Development (Cambridge) 2006-04, Vol.133 (8), p.1565-1573
Hauptverfasser:	Nowotschin, Sonja, Liao, Jun, Gage, Philip J, Epstein, Jonathan A, Campione, Marina, Morrow, Bernice E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enhancer Elements, Genetic - physiology Gene Expression Regulation, Developmental - physiology Heart - embryology Heart - physiology Homeobox Protein Nkx-2.5 Homeobox Protein PITX2 Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeodomain Proteins - physiology Mice Mice, Mutant Strains Mutation Myocardium - cytology Myocardium - metabolism Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Nuclear Proteins - physiology T-Box Domain Proteins - biosynthesis T-Box Domain Proteins - genetics T-Box Domain Proteins - physiology Transcription Factors - metabolism Transcription Factors - physiology
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