Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China
Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case‐control study comparing the Se content in toenail clippings of 166 individu...
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| Veröffentlicht in: | International journal of cancer 2005-07, Vol.115 (4), p.618-624 |
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| creator | Sakoda, Lori C. Graubard, Barry I. Evans, Alison A. London, W. Thomas Lin, Wen‐Yao Shen, Fu‐Min McGlynn, Katherine A. |
| description | Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case‐control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma‐optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls (p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32–1.03), 0.83 (0.48–1.42) and 0.50 (0.28–0.90), with a marginally significant trend in risk observed (p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.20937 |
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Thomas ; Lin, Wen‐Yao ; Shen, Fu‐Min ; McGlynn, Katherine A.</creator><creatorcontrib>Sakoda, Lori C. ; Graubard, Barry I. ; Evans, Alison A. ; London, W. Thomas ; Lin, Wen‐Yao ; Shen, Fu‐Min ; McGlynn, Katherine A.</creatorcontrib><description>Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case‐control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma‐optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls (p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32–1.03), 0.83 (0.48–1.42) and 0.50 (0.28–0.90), with a marginally significant trend in risk observed (p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.20937</identifier><identifier>PMID: 15704105</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Alcohol Drinking ; Biological and medical sciences ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; China - epidemiology ; epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis - epidemiology ; Hepatitis B Surface Antigens - blood ; Humans ; liver ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Nails - chemistry ; neoplasm ; Occupations ; selenium ; Selenium - analysis ; Sex Characteristics ; Smoking ; Tropical medicine ; Tumors ; Urban Population</subject><ispartof>International journal of cancer, 2005-07, Vol.115 (4), p.618-624</ispartof><rights>Published 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3847-e56677c8c85302638e0f8b5beb2759f657f7e2e2c23edecbc21e8223f2f9f3c43</citedby><cites>FETCH-LOGICAL-c3847-e56677c8c85302638e0f8b5beb2759f657f7e2e2c23edecbc21e8223f2f9f3c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.20937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.20937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16772317$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15704105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakoda, Lori C.</creatorcontrib><creatorcontrib>Graubard, Barry I.</creatorcontrib><creatorcontrib>Evans, Alison A.</creatorcontrib><creatorcontrib>London, W. Thomas</creatorcontrib><creatorcontrib>Lin, Wen‐Yao</creatorcontrib><creatorcontrib>Shen, Fu‐Min</creatorcontrib><creatorcontrib>McGlynn, Katherine A.</creatorcontrib><title>Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case‐control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma‐optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls (p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32–1.03), 0.83 (0.48–1.42) and 0.50 (0.28–0.90), with a marginally significant trend in risk observed (p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. © 2005 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Alcohol Drinking</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>China - epidemiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis - epidemiology</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Humans</subject><subject>liver</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nails - chemistry</subject><subject>neoplasm</subject><subject>Occupations</subject><subject>selenium</subject><subject>Selenium - analysis</subject><subject>Sex Characteristics</subject><subject>Smoking</subject><subject>Tropical medicine</subject><subject>Tumors</subject><subject>Urban Population</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl4WvoBkoyDYmVyapl1K8cqAG12XNHPCRNN0TFpk3t6MM-BKXB0O5-P7Dz9C55RMKSFsZt_1lJGKyz00oaSSGWFU7KNJupFMUl4coeMY3wmhVJD8EB1RIUlOiZigt9cevLIOR3Dg7dhh5Rc42PiBe4OXsFJDr8G50amAtQra-r5TuOvDoJwd1th6_KhsBx7Xab3B9dJ6dYoOjHIRznbzBL3d373Wj9n85eGpvp1nmpe5zEAUhZS61KXghBW8BGLKVrTQMikqUwhpJDBgmnFYgG41o1Ayxg0zleE65yfoautdhf5zhDg0nY2bd5WHfoxNssuKJ_N_IJWlqCohE3i9BXXoYwxgmlWwnQrrhpJmU3aTym5-yk7sxU46th0sfslduwm43AEqauVMUF7b-Mul9xinG9Fsy31ZB-u_E5un53ob_Q3aBJUt</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Sakoda, Lori C.</creator><creator>Graubard, Barry I.</creator><creator>Evans, Alison A.</creator><creator>London, W. Thomas</creator><creator>Lin, Wen‐Yao</creator><creator>Shen, Fu‐Min</creator><creator>McGlynn, Katherine A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China</title><author>Sakoda, Lori C. ; Graubard, Barry I. ; Evans, Alison A. ; London, W. Thomas ; Lin, Wen‐Yao ; Shen, Fu‐Min ; McGlynn, Katherine A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-e56677c8c85302638e0f8b5beb2759f657f7e2e2c23edecbc21e8223f2f9f3c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Alcohol Drinking</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>China - epidemiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis - epidemiology</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Humans</topic><topic>liver</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nails - chemistry</topic><topic>neoplasm</topic><topic>Occupations</topic><topic>selenium</topic><topic>Selenium - analysis</topic><topic>Sex Characteristics</topic><topic>Smoking</topic><topic>Tropical medicine</topic><topic>Tumors</topic><topic>Urban Population</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakoda, Lori C.</creatorcontrib><creatorcontrib>Graubard, Barry I.</creatorcontrib><creatorcontrib>Evans, Alison A.</creatorcontrib><creatorcontrib>London, W. Thomas</creatorcontrib><creatorcontrib>Lin, Wen‐Yao</creatorcontrib><creatorcontrib>Shen, Fu‐Min</creatorcontrib><creatorcontrib>McGlynn, Katherine A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakoda, Lori C.</au><au>Graubard, Barry I.</au><au>Evans, Alison A.</au><au>London, W. Thomas</au><au>Lin, Wen‐Yao</au><au>Shen, Fu‐Min</au><au>McGlynn, Katherine A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>115</volume><issue>4</issue><spage>618</spage><epage>624</epage><pages>618-624</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case‐control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma‐optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls (p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32–1.03), 0.83 (0.48–1.42) and 0.50 (0.28–0.90), with a marginally significant trend in risk observed (p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15704105</pmid><doi>10.1002/ijc.20937</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Alcohol Drinking Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality China - epidemiology epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis - epidemiology Hepatitis B Surface Antigens - blood Humans liver Liver Neoplasms - genetics Liver Neoplasms - mortality Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Nails - chemistry neoplasm Occupations selenium Selenium - analysis Sex Characteristics Smoking Tropical medicine Tumors Urban Population |
| title | Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China |
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