Regulatory T Cells Are Expanded in Blood and Disease Sites in Patients with Tuberculosis

T-cell responses during tuberculosis (TB) help contain Mycobacterium tuberculosis in vivo but also cause collateral damage to host tissues. Immune regulatory mechanisms may limit this immunopathology, and suppressed cellular immune responses in patients with TB suggest the presence of regulatory act...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2006-04, Vol.173 (7), p.803-810
Hauptverfasser:	Guyot-Revol, Valerie, Innes, John A, Hackforth, Sarah, Hinks, Tim, Lalvani, Ajit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Female Flow Cytometry Forkhead Transcription Factors - genetics Gene Expression Humans Intensive care medicine Interleukin-10 - genetics Lymphocyte Activation Male Medical sciences Middle Aged Receptors, Interleukin-2 - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta - genetics Transforming Growth Factor beta1 Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tuberculosis - blood Tuberculosis - immunology Tuberculosis - pathology
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