The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells

The serpin SPI-3 and the hemagglutinin (HA) encoded by cowpox virus (CPV) block cell–cell fusion, and colocalize at the cell surface. wtCPV does not fuse cells, but inactivation of either gene leads to fusion. SPI-3 mAb added to wtCPV-infected cells caused fusion, confirming that SPI-3 protein at th...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2006-03, Vol.347 (1), p.88-99
Hauptverfasser:	Turner, Peter C., Moyer, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal Antibodies, Viral Cell Line Cell Membrane - virology Cell–cell fusion Cercopithecus aethiops Coimmunoprecipitation Cowpox virus Cowpox virus - genetics Cowpox virus - immunology Cowpox virus - pathogenicity Cowpox virus - physiology Epitope Mapping Hemagglutinin (HA) Hemagglutinins, Viral - genetics Hemagglutinins, Viral - immunology Hemagglutinins, Viral - physiology Membrane Fusion - genetics Membrane Fusion - physiology Models, Molecular Molecular Sequence Data Mutation Poxvirus Protein Conformation Protein–protein interaction Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Sequence Homology, Amino Acid Serpin Serpins - chemistry Serpins - genetics Serpins - immunology Serpins - physiology SPI-3 Transfection Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - immunology Viral Proteins - physiology
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