Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia

OBJECTIVE—This study characterized the role of insulin receptors and resistance on vascular endothelial growth factor (VEGF) expression and myocardial vascularization in physiological conditions and after ischemia. METHODS AND RESULTS—Cardiac microvascular density was reduced by 30% in insulin-resis...

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Veröffentlicht in:Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2006-04, Vol.26 (4), p.787-793
Hauptverfasser: He, Zhiheng, Opland, Darren M, Way, Kerrie J, Ueki, Kohjiro, Bodyak, Natalya, Kang, Peter M, Izumo, Seigo, Kulkarni, Rohit N, Wang, Bo, Liao, Ronglih, Kahn, C Ronald, King, George L
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Sprache:eng
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