Beta-Blockers to Prevent Gastroesophageal Varices in Cirrhosis
To the Editor: The report by Groszmann et al. (Nov. 24 issue) 1 answers a question my colleagues and I first raised several years ago 2 — namely, that of the potential value of nonselective beta-blockade in the treatment of unselected patients with cirrhosis. We hypothesized that the use of nonselec...
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| Veröffentlicht in: | The New England journal of medicine 2006-03, Vol.354 (12), p.1318-1320 |
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| container_title | The New England journal of medicine |
| container_volume | 354 |
| creator | Post, Anthony B |
| description | To the Editor:
The report by Groszmann et al. (Nov. 24 issue)
1
answers a question my colleagues and I first raised several years ago
2
— namely, that of the potential value of nonselective beta-blockade in the treatment of unselected patients with cirrhosis. We hypothesized that the use of nonselective beta-blockers would lead to a lower rate of esophageal variceal hemorrhage, death, or both, if these agents were given to all such patients.
With regard to the study by Groszmann et al., the classification of a therapy-induced drop in the heart rate to below 50 beats per minute as a serious . . . |
| doi_str_mv | 10.1056/NEJMc053519 |
| format | Article |
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The report by Groszmann et al. (Nov. 24 issue)
1
answers a question my colleagues and I first raised several years ago
2
— namely, that of the potential value of nonselective beta-blockade in the treatment of unselected patients with cirrhosis. We hypothesized that the use of nonselective beta-blockers would lead to a lower rate of esophageal variceal hemorrhage, death, or both, if these agents were given to all such patients.
With regard to the study by Groszmann et al., the classification of a therapy-induced drop in the heart rate to below 50 beats per minute as a serious . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc053519</identifier><identifier>PMID: 16554538</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adrenergic beta-Antagonists - adverse effects ; Adrenergic beta-Antagonists - therapeutic use ; Bradycardia - chemically induced ; Esophageal and Gastric Varices - prevention & control ; Gastrointestinal Hemorrhage - prevention & control ; Heart Rate - drug effects ; Humans ; Hypertension, Portal - drug therapy ; Liver Cirrhosis - complications</subject><ispartof>The New England journal of medicine, 2006-03, Vol.354 (12), p.1318-1320</ispartof><rights>Copyright © 2006 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-7b2570fccb62d4741d1e17f4cc4db437768907ac80f2ee3dab887babf2bb0b0c3</citedby><cites>FETCH-LOGICAL-c385t-7b2570fccb62d4741d1e17f4cc4db437768907ac80f2ee3dab887babf2bb0b0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc053519$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMc053519$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26082,27903,27904,52360,54042</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16554538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Post, Anthony B</creatorcontrib><title>Beta-Blockers to Prevent Gastroesophageal Varices in Cirrhosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
The report by Groszmann et al. (Nov. 24 issue)
1
answers a question my colleagues and I first raised several years ago
2
— namely, that of the potential value of nonselective beta-blockade in the treatment of unselected patients with cirrhosis. We hypothesized that the use of nonselective beta-blockers would lead to a lower rate of esophageal variceal hemorrhage, death, or both, if these agents were given to all such patients.
With regard to the study by Groszmann et al., the classification of a therapy-induced drop in the heart rate to below 50 beats per minute as a serious . . .</description><subject>Adrenergic beta-Antagonists - adverse effects</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Bradycardia - chemically induced</subject><subject>Esophageal and Gastric Varices - prevention & control</subject><subject>Gastrointestinal Hemorrhage - prevention & control</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypertension, Portal - drug therapy</subject><subject>Liver Cirrhosis - complications</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPwzAURi0EouUxsaNISCwoYMd27CxItCoFVB4DsEa2c0NTkrj4pkj8e4JaCQa-5VuOznAIOWL0nFGZXjxM7u4dlVyybIsMmeQ8FoKm22RIaaJjoTI-IHuIC9qPiWyXDFgqpZBcD8nlCDoTj2rv3iFg1PnoKcAntF00NdgFD-iXc_MGpo5eTagcYFS10bgKYe6xwgOyU5oa4XDz--TlevI8volnj9Pb8dUsdlzLLlY2kYqWztk0KYQSrGDAVCmcE4UVXKlUZ1QZp2mZAPDCWK2VNbZMrKWWOr5PTtfeZfAfK8Aubyp0UNemBb_CPFX9pEx78GwNuuARA5T5MlSNCV85o_lPrvxPrp4-3mhXtoHil9306YGTNdA0mLewaP7VfAM6iXAT</recordid><startdate>20060323</startdate><enddate>20060323</enddate><creator>Post, Anthony B</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060323</creationdate><title>Beta-Blockers to Prevent Gastroesophageal Varices in Cirrhosis</title><author>Post, Anthony B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-7b2570fccb62d4741d1e17f4cc4db437768907ac80f2ee3dab887babf2bb0b0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenergic beta-Antagonists - adverse effects</topic><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Bradycardia - chemically induced</topic><topic>Esophageal and Gastric Varices - prevention & control</topic><topic>Gastrointestinal Hemorrhage - prevention & control</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypertension, Portal - drug therapy</topic><topic>Liver Cirrhosis - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Post, Anthony B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Post, Anthony B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-Blockers to Prevent Gastroesophageal Varices in Cirrhosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2006-03-23</date><risdate>2006</risdate><volume>354</volume><issue>12</issue><spage>1318</spage><epage>1320</epage><pages>1318-1320</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
The report by Groszmann et al. (Nov. 24 issue)
1
answers a question my colleagues and I first raised several years ago
2
— namely, that of the potential value of nonselective beta-blockade in the treatment of unselected patients with cirrhosis. We hypothesized that the use of nonselective beta-blockers would lead to a lower rate of esophageal variceal hemorrhage, death, or both, if these agents were given to all such patients.
With regard to the study by Groszmann et al., the classification of a therapy-induced drop in the heart rate to below 50 beats per minute as a serious . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>16554538</pmid><doi>10.1056/NEJMc053519</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2006-03, Vol.354 (12), p.1318-1320 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adrenergic beta-Antagonists - adverse effects Adrenergic beta-Antagonists - therapeutic use Bradycardia - chemically induced Esophageal and Gastric Varices - prevention & control Gastrointestinal Hemorrhage - prevention & control Heart Rate - drug effects Humans Hypertension, Portal - drug therapy Liver Cirrhosis - complications |
| title | Beta-Blockers to Prevent Gastroesophageal Varices in Cirrhosis |
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