A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data

Correlating the activation foci identified in functional imaging studies of the human brain with structural (e.g., cytoarchitectonic) information on the activated areas is a major methodological challenge for neuroscience research. We here present a new approach to make use of three-dimensional prob...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2005-05, Vol.25 (4), p.1325-1335
Hauptverfasser: Eickhoff, Simon B., Stephan, Klaas E., Mohlberg, Hartmut, Grefkes, Christian, Fink, Gereon R., Amunts, Katrin, Zilles, Karl
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container_issue 4
container_start_page 1325
container_title NeuroImage (Orlando, Fla.)
container_volume 25
creator Eickhoff, Simon B.
Stephan, Klaas E.
Mohlberg, Hartmut
Grefkes, Christian
Fink, Gereon R.
Amunts, Katrin
Zilles, Karl
description Correlating the activation foci identified in functional imaging studies of the human brain with structural (e.g., cytoarchitectonic) information on the activated areas is a major methodological challenge for neuroscience research. We here present a new approach to make use of three-dimensional probabilistic cytoarchitectonic maps, as obtained from the analysis of human post-mortem brains, for correlating microscopical, anatomical and functional imaging data of the cerebral cortex. We introduce a new, MATLAB based toolbox for the SPM2 software package which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies. The toolbox includes the functionality for the construction of summary maps combining probability of several cortical areas by finding the most probable assignment of each voxel to one of these areas. Its main feature is to provide several measures defining the degree of correspondence between architectonic areas and functional foci. The software, together with the presently available probability maps, is available as open source software to the neuroimaging community. This new toolbox provides an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
doi_str_mv 10.1016/j.neuroimage.2004.12.034
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subjects Brain
Brain - anatomy & histology
Brain Mapping - methods
Cluster Analysis
Functional magnetic resonance imaging
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging
Mapping
Medical imaging
Models, Statistical
PET
Semantics
Software
Software packages
Structure
Studies
User interface
title A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
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