MEK-ERK Signaling Controls Hdm2 Oncoprotein Expression by Regulating hdm2 mRNA Export to the Cytoplasm

The physical and functional interaction between the transcription factor p53 and its negative regulatory partner protein Hdm2 (Mdm2 in mouse) is a key point of convergence of multiple signaling pathways that regulates cell proliferation and survival. hdm2 mRNA transcription is induced by p53, formin...

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Veröffentlicht in:	The Journal of biological chemistry 2005-04, Vol.280 (17), p.16651-16658
Hauptverfasser:	Phelps, Monika, Phillips, Anna, Darley, Matthew, Blaydes, Jeremy P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Butadienes - pharmacology Cell Cycle Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation Cell Survival Cytoplasm - metabolism Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Neoplastic Genes, Reporter Humans In Situ Hybridization Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinase Kinases - physiology Models, Biological Nitriles - pharmacology Nuclear Proteins - biosynthesis Nuclear Proteins - metabolism Nuclear Proteins - physiology Plasmids - metabolism Protein Binding Protein Transport Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-mdm2 RNA - metabolism RNA Processing, Post-Transcriptional RNA, Messenger - metabolism Time Factors Transcription, Genetic Tumor Suppressor Protein p53 - metabolism
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