Inhibition of hepatitis B virus replication in 2.2.15 cells by expressed shRNA

Hepatitis B virus (HBV) infection is a worldwide health problem. To determine whether RNA interference (RNAi) could inhibit ongoing HBV replication in 2.2.15 cells, we constructed shRNA‐producing vector pU6P based on the mouse U6 RNA promoter and cloned 12 targeted sequences against HBV into the vec...

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Veröffentlicht in:	Journal of viral hepatitis 2005-05, Vol.12 (3), p.236-242
Hauptverfasser:	Ren, X.-R., Zhou, L.-J., Luo, G.-B., Lin, B., Xu, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2.2.15 cell Animals Base Sequence Cells, Cultured DNA Replication DNA, Viral - metabolism Enzyme-Linked Immunosorbent Assay Gene Expression Regulation, Viral Genetic Therapy - methods Genetic Vectors - pharmacology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - physiology Humans Mice Molecular Sequence Data Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction RNA Interference Sensitivity and Specificity shRNA Transfection U6 promoter Viral Proteins - metabolism Virus Replication
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