A dose-finding study of duloxetine based on serotonin transporter occupancy

Positron emission tomography (PET) has been utilized for determining the dosage of antipsychotic drugs. To evaluate the dosage of antidepressants such as selective serotonin reuptake inhibitors, serotonin transporter occupancy (5-HTT) is also a useful index. We investigated the degree of 5-HTT occup...

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Veröffentlicht in:	Psychopharmacologia 2006-04, Vol.185 (3), p.395-399
Hauptverfasser:	TAKANO, Akihiro, SUZUKI, Kazutoshi, KOSAKA, Jun, OTA, Miho, NOZAKI, Shoko, IKOMA, Yoko, TANADA, Shuji, SUHARA, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Dose-Response Relationship, Drug Duloxetine Hydrochloride Humans Magnetic Resonance Imaging Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Positron-Emission Tomography Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - blood Thiophenes - administration & dosage Thiophenes - blood
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