Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells

We have reported previously the isolation of three photodynamic therapy (PDT)-resistant human colon carcinoma HT29 cell lines that show increased expression of the Hsp27 and BNip3 protein and a decreased expression of the mutant p53 protein compared to parental HT29 cells. Since mutant p53 and incre...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-06, Vol.331 (2), p.648-657
Hauptverfasser:	Zacal, Natalie, Espiritu, Myrna, Singh, Gurmit, Rainbow, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Apoptosis Apoptosis - drug effects BNip3 Cell Survival - drug effects Cisplatin - pharmacology Cisplatin sensitivity Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - drug effects Genes, p53 - genetics Heat-Shock Proteins - metabolism Hsp27 HSP27 Heat-Shock Proteins HT29 Cells Humans Membrane Proteins - metabolism Mutation - genetics Neoplasm Proteins - metabolism p53 PDT resistance Photochemotherapy Proto-Oncogene Proteins - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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