Immunolipoplexes: An Efficient, Nonviral Alternative for Transfection of Human Dendritic Cells with Potential for Clinical Vaccination

Genetic manipulation of dendritic cells (DCs) is important in the context of using either mature DCs to immunize patients or immature DCs to induce tolerance. Here, we describe a novel method of transfecting monocyte-derived human DCs using immunolipoplexes containing anti-CD71 or anti-CD205 monoclo...

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Veröffentlicht in:	Molecular therapy 2005-05, Vol.11 (5), p.790-800
Hauptverfasser:	Tan, Peng H., Beutelspacher, Sven C., Wang, Yao-He, McClure, Myra O., Ritter, Mary A., Lombardi, Giovanna, George, Andrew J.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Antigens Antigens, CD - immunology Antigens, Differentiation, B-Lymphocyte - immunology Cell Differentiation Cells, Cultured Coculture Techniques Cytokines Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - transplantation Efficiency Gene Expression Gene therapy Genetic engineering Genetic Vectors - genetics Genotype & phenotype Hospitals Humans Indoleamine-Pyrrole 2,3,-Dioxygenase Lectins, C-Type - immunology Lipids Liposomes - administration & dosage Liposomes - immunology Lymphocytes Mice Minor Histocompatibility Antigens Phenotype Receptors, Cell Surface - immunology Receptors, Transferrin T-Lymphocytes - immunology T-Lymphocytes - metabolism Toxicity Transfection - instrumentation Tryptophan Oxygenase - genetics Tryptophan Oxygenase - metabolism Vaccination - methods Vectors (Biology)
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