Effects of the angiogenesis inhibitor angiostatin on the growth of CC531 colon carcinoma cells in vitro and in a laparoscopic animal model of peritoneal carcinomatosis

As angiogenesis is one of the key steps in tumor growth, invasion, and metastasis, antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. We investigated the cytotoxic, anti-adhesive, and anti-invasive effects of angiostatin in vitro and on intraperitoneal tumor gro...

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Veröffentlicht in:	International journal of colorectal disease 2006-05, Vol.21 (4), p.314-320
Hauptverfasser:	NESTLER, G, SCHULZ, H. U, TAUTENHAHN, J, KUHN, R, KRUGER, S, LIPPERT, H, PROSS, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adenocarcinoma - pathology Angiogenesis Inhibitors - pharmacology Angiostatins - pharmacology Animals Biological and medical sciences Cell Adhesion - drug effects Cell Line, Tumor - drug effects Colonic Neoplasms - pathology Digestive system. Abdomen Disease Models, Animal Dose-Response Relationship, Drug Endoscopy Gastroenterology. Liver. Pancreas. Abdomen Injections, Intraperitoneal Injections, Subcutaneous Investigative techniques, diagnostic techniques (general aspects) Laparoscopy Male Medical sciences Neoplasm Transplantation Neovascularization, Pathologic - prevention & control Peritoneal Neoplasms - blood supply Peritoneal Neoplasms - pathology Pneumoperitoneum, Artificial Random Allocation Rats Rats, Wistar Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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