A Regioselective Tryptophan 5-Halogenase Is Involved in Pyrroindomycin Biosynthesis in Streptomyces rugosporus LL-42D005

The antibiotic compound pyrroindomycin B contains an indole ring chlorinated in the 5 position. The indole ring is probably derived from tryptophan, and thus primers derived from conserved regions of tryptophan halogenases were used to amplify and clone a DNA fragment that was then used to isolate a...

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Veröffentlicht in:	Chemistry & biology 2005-04, Vol.12 (4), p.445-452
Hauptverfasser:	Zehner, Susanne, Kotzsch, Alexander, Bister, Bojan, Süssmuth, Roderich D., Méndez, Carmen, Salas, José A., van Pée, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - biosynthesis Chromatography, High Pressure Liquid Cloning, Molecular DNA, Fungal - chemistry DNA, Fungal - genetics Electrophoresis, Polyacrylamide Gel Gene Expression Regulation, Enzymologic - genetics Genes, Fungal Genetic Vectors Macrolides - metabolism Magnetic Resonance Spectroscopy Molecular Sequence Data Mutation - genetics Oxidoreductases - genetics Oxidoreductases - isolation & purification Oxidoreductases - metabolism Plasmids - genetics Reverse Transcriptase Polymerase Chain Reaction Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet Streptomyces - enzymology Streptomyces - genetics Streptomyces - metabolism
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