Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors

Summary 1 The involvement of Ca2+ sensitization mediated through Rho kinase in the contractility of rat epididymal vas deferens was investigated using Rho kinase inhibitors, trans‐4‐[(1R)‐1‐aminoethyl]‐N‐4‐pyridinilcyclohexanecarboxamide dihydrochloride (Y‐27632) and 1‐(5‐isoquinolinesulphonyl)homop...

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Veröffentlicht in:	Autonomic & autacoid pharmacology 2006-04, Vol.26 (2), p.169-181
Hauptverfasser:	Amobi, N. I. B., Chung, I.-P., Smith, I. C. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Amides - pharmacology Animals Azepines - pharmacology Calcium - metabolism Dose-Response Relationship, Drug Egtazic Acid HA 1077 high [K+]o In Vitro Techniques Intracellular Signaling Peptides and Proteins LY 294002 Male ML-9 Muscle Contraction Muscle, Smooth - drug effects Muscle, Smooth - physiology Myosin-Light-Chain Kinase - antagonists & inhibitors Myosin-Light-Chain Kinase - metabolism noradrenaline Norepinephrine - pharmacology Potassium - metabolism Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Purinergic P2 Receptor Agonists Pyridines - pharmacology R59949 rat vas deferens Rats Rats, Sprague-Dawley Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X RHC-80267 rho-Associated Kinases Vas Deferens - drug effects Vas Deferens - physiology wortmannin Y-27632 α,β‐methylene ATP β-methylene ATP
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