The level of antibody against E6 HPV 16 oncoprotein in blood sera of women with chronic HPV 16 infection and cervical cancer
The aim of this study was to estimate of the role of chronic HPV 16 infection and the presence of anti E6 HPV 16 in the initiation of the cancerogenesis process of cervical cancer. The study included two groups of patients. The first group comprised 323 women observed for three consecutive years (19...
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| Veröffentlicht in: | European journal of gynaecological oncology 2006, Vol.27 (1), p.65-68 |
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| container_title | European journal of gynaecological oncology |
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| creator | Kedzia, W Olejnik, A Schmidt, M Nawrot, R Goździcka-Józefiak, A Kedzia, H Spaczyński, M |
| description | The aim of this study was to estimate of the role of chronic HPV 16 infection and the presence of anti E6 HPV 16 in the initiation of the cancerogenesis process of cervical cancer.
The study included two groups of patients. The first group comprised 323 women observed for three consecutive years (1998-2000), in whom the presence of HPV 16 viruses was estimated by PCR, and the level of anti E6 HPV 16 antibodies was estimated in the plasma with ELISA. A similar test was performed in a group of 46 patients with cervical intraepithelial neoplasia (CIN), 91 patients with invasive cervical cancer and 22 women after hysterectomy and RTG-therapy.
In 32 patients, chronic HPV 16 infection showed a steady rise in the mean absorbance level of anti E6 HPV 16 antibodies from 0.04 in 1998 to 0.06 in 2000, while in HPV-negative women the mean absorbance value was 0.03-0.04. Mean absorbance value in patients with CIN III and invasive cancer rose with advancing stage of the cancer process and lowered after completion of oncological treatment. The values were 0.14, 0.33 and 0.13, respectively.
The persistence of chronic HPV 16 infection and accompanying steady rise in absorbance index caused by an increase in the level of antiviral antibodies are a clear warning signal preceding in time the histological process of cancerogenesis. |
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The study included two groups of patients. The first group comprised 323 women observed for three consecutive years (1998-2000), in whom the presence of HPV 16 viruses was estimated by PCR, and the level of anti E6 HPV 16 antibodies was estimated in the plasma with ELISA. A similar test was performed in a group of 46 patients with cervical intraepithelial neoplasia (CIN), 91 patients with invasive cervical cancer and 22 women after hysterectomy and RTG-therapy.
In 32 patients, chronic HPV 16 infection showed a steady rise in the mean absorbance level of anti E6 HPV 16 antibodies from 0.04 in 1998 to 0.06 in 2000, while in HPV-negative women the mean absorbance value was 0.03-0.04. Mean absorbance value in patients with CIN III and invasive cancer rose with advancing stage of the cancer process and lowered after completion of oncological treatment. The values were 0.14, 0.33 and 0.13, respectively.
The persistence of chronic HPV 16 infection and accompanying steady rise in absorbance index caused by an increase in the level of antiviral antibodies are a clear warning signal preceding in time the histological process of cancerogenesis.</description><identifier>ISSN: 0392-2936</identifier><identifier>PMID: 16550973</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Antibodies, Viral - blood ; Biomarkers - analysis ; Case-Control Studies ; Cell Transformation, Neoplastic - pathology ; Chronic Disease ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Human papillomavirus 16 - immunology ; Human papillomavirus 16 - isolation & purification ; Humans ; Hysterectomy - methods ; Incidence ; Middle Aged ; Oncogene Proteins, Viral - blood ; Papillomavirus Infections - diagnosis ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - immunology ; Retrospective Studies ; Risk Assessment ; Tumor Virus Infections - diagnosis ; Tumor Virus Infections - immunology ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - surgery ; Uterine Cervical Neoplasms - virology</subject><ispartof>European journal of gynaecological oncology, 2006, Vol.27 (1), p.65-68</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16550973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kedzia, W</creatorcontrib><creatorcontrib>Olejnik, A</creatorcontrib><creatorcontrib>Schmidt, M</creatorcontrib><creatorcontrib>Nawrot, R</creatorcontrib><creatorcontrib>Goździcka-Józefiak, A</creatorcontrib><creatorcontrib>Kedzia, H</creatorcontrib><creatorcontrib>Spaczyński, M</creatorcontrib><title>The level of antibody against E6 HPV 16 oncoprotein in blood sera of women with chronic HPV 16 infection and cervical cancer</title><title>European journal of gynaecological oncology</title><addtitle>Eur J Gynaecol Oncol</addtitle><description>The aim of this study was to estimate of the role of chronic HPV 16 infection and the presence of anti E6 HPV 16 in the initiation of the cancerogenesis process of cervical cancer.
The study included two groups of patients. The first group comprised 323 women observed for three consecutive years (1998-2000), in whom the presence of HPV 16 viruses was estimated by PCR, and the level of anti E6 HPV 16 antibodies was estimated in the plasma with ELISA. A similar test was performed in a group of 46 patients with cervical intraepithelial neoplasia (CIN), 91 patients with invasive cervical cancer and 22 women after hysterectomy and RTG-therapy.
In 32 patients, chronic HPV 16 infection showed a steady rise in the mean absorbance level of anti E6 HPV 16 antibodies from 0.04 in 1998 to 0.06 in 2000, while in HPV-negative women the mean absorbance value was 0.03-0.04. Mean absorbance value in patients with CIN III and invasive cancer rose with advancing stage of the cancer process and lowered after completion of oncological treatment. The values were 0.14, 0.33 and 0.13, respectively.
The persistence of chronic HPV 16 infection and accompanying steady rise in absorbance index caused by an increase in the level of antiviral antibodies are a clear warning signal preceding in time the histological process of cancerogenesis.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>Biomarkers - analysis</subject><subject>Case-Control Studies</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Chronic Disease</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human papillomavirus 16 - immunology</subject><subject>Human papillomavirus 16 - isolation & purification</subject><subject>Humans</subject><subject>Hysterectomy - methods</subject><subject>Incidence</subject><subject>Middle Aged</subject><subject>Oncogene Proteins, Viral - blood</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Papillomavirus Infections - immunology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Tumor Virus Infections - diagnosis</subject><subject>Tumor Virus Infections - immunology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - surgery</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0392-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1LAzEU3INia_UvyDt5W9jPZHOUUq1Q0EP1urxkX2wkm9RN2lLwx7vFFgZmDjMDM1fJNCtFkRaiZJPkNoTvLKsqzoqbZJKzus4EL6fJ73pDYGlPFrwGdNFI3x0Bv9C4EGHBYPn-CTkD75TfDj6ScTBCWu87CDTgKXfwPTk4mLgBtRm8M-oSM06Tisa7sbsDRcPeKLSg0I36LrnWaAPdn3mWfDwv1vNlunp7eZ0_rdJtkYmY1kI22DWSo6qagjOWk1BCskZmvNY645I073JRS50zJnmOWHEldIVdJaTEcpY8_veOA352FGLbm6DIWnTkd6FlnPOyLsVofDgbd7Knrt0Opsfh2F7-Kv8A3t9mQw</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Kedzia, W</creator><creator>Olejnik, A</creator><creator>Schmidt, M</creator><creator>Nawrot, R</creator><creator>Goździcka-Józefiak, A</creator><creator>Kedzia, H</creator><creator>Spaczyński, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>The level of antibody against E6 HPV 16 oncoprotein in blood sera of women with chronic HPV 16 infection and cervical cancer</title><author>Kedzia, W ; Olejnik, A ; Schmidt, M ; Nawrot, R ; Goździcka-Józefiak, A ; Kedzia, H ; Spaczyński, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-59b8ad8b7ac4827661e9c9b68b075ff07bef7d195bf166b71aa47c9f4ad49bba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>Biomarkers - analysis</topic><topic>Case-Control Studies</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Chronic Disease</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human papillomavirus 16 - immunology</topic><topic>Human papillomavirus 16 - isolation & purification</topic><topic>Humans</topic><topic>Hysterectomy - methods</topic><topic>Incidence</topic><topic>Middle Aged</topic><topic>Oncogene Proteins, Viral - blood</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Papillomavirus Infections - immunology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Tumor Virus Infections - diagnosis</topic><topic>Tumor Virus Infections - immunology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - surgery</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kedzia, W</creatorcontrib><creatorcontrib>Olejnik, A</creatorcontrib><creatorcontrib>Schmidt, M</creatorcontrib><creatorcontrib>Nawrot, R</creatorcontrib><creatorcontrib>Goździcka-Józefiak, A</creatorcontrib><creatorcontrib>Kedzia, H</creatorcontrib><creatorcontrib>Spaczyński, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gynaecological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kedzia, W</au><au>Olejnik, A</au><au>Schmidt, M</au><au>Nawrot, R</au><au>Goździcka-Józefiak, A</au><au>Kedzia, H</au><au>Spaczyński, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The level of antibody against E6 HPV 16 oncoprotein in blood sera of women with chronic HPV 16 infection and cervical cancer</atitle><jtitle>European journal of gynaecological oncology</jtitle><addtitle>Eur J Gynaecol Oncol</addtitle><date>2006</date><risdate>2006</risdate><volume>27</volume><issue>1</issue><spage>65</spage><epage>68</epage><pages>65-68</pages><issn>0392-2936</issn><abstract>The aim of this study was to estimate of the role of chronic HPV 16 infection and the presence of anti E6 HPV 16 in the initiation of the cancerogenesis process of cervical cancer.
The study included two groups of patients. The first group comprised 323 women observed for three consecutive years (1998-2000), in whom the presence of HPV 16 viruses was estimated by PCR, and the level of anti E6 HPV 16 antibodies was estimated in the plasma with ELISA. A similar test was performed in a group of 46 patients with cervical intraepithelial neoplasia (CIN), 91 patients with invasive cervical cancer and 22 women after hysterectomy and RTG-therapy.
In 32 patients, chronic HPV 16 infection showed a steady rise in the mean absorbance level of anti E6 HPV 16 antibodies from 0.04 in 1998 to 0.06 in 2000, while in HPV-negative women the mean absorbance value was 0.03-0.04. Mean absorbance value in patients with CIN III and invasive cancer rose with advancing stage of the cancer process and lowered after completion of oncological treatment. The values were 0.14, 0.33 and 0.13, respectively.
The persistence of chronic HPV 16 infection and accompanying steady rise in absorbance index caused by an increase in the level of antiviral antibodies are a clear warning signal preceding in time the histological process of cancerogenesis.</abstract><cop>Italy</cop><pmid>16550973</pmid><tpages>4</tpages></addata></record> |
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| subjects | Adult Antibodies, Viral - blood Biomarkers - analysis Case-Control Studies Cell Transformation, Neoplastic - pathology Chronic Disease Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Human papillomavirus 16 - immunology Human papillomavirus 16 - isolation & purification Humans Hysterectomy - methods Incidence Middle Aged Oncogene Proteins, Viral - blood Papillomavirus Infections - diagnosis Papillomavirus Infections - epidemiology Papillomavirus Infections - immunology Retrospective Studies Risk Assessment Tumor Virus Infections - diagnosis Tumor Virus Infections - immunology Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery Uterine Cervical Neoplasms - virology |
| title | The level of antibody against E6 HPV 16 oncoprotein in blood sera of women with chronic HPV 16 infection and cervical cancer |
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