Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism

Experimental evidence indicates that reactive oxygen species (ROS) are involved in the development of hepatic fibrosis; they induce hepatic stellate cells (HSC) proliferation and collagen synthesis. To address the role of matrix metalloproteinase (MMP)-2 in promoting HSC proliferation during hepatic...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2005-05, Vol.41 (5), p.1074-1084
Hauptverfasser:	GALLI, Andrea, SVEGLIATI-BARONI, Gianluca, SURRENTI, Calogero, CASINI, Alessandro, CENI, Elisabetta, MILANI, Stefano, RIDOLFI, Francesco, SALZANO, Renata, TAROCCHI, Mirko, GRAPPONE, Cecilia, PELLEGRINI, Giulia, BENEDETTI, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Division - drug effects Cell Division - physiology Cells, Cultured Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Hepatocytes - cytology Hepatocytes - enzymology Humans Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver. Bile. Biliary tracts Liver. Biliary tract. Portal circulation. Exocrine pancreas Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinases, Membrane-Associated Medical sciences Metalloendopeptidases - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Other diseases. Semiology Oxidative Stress - drug effects Oxidative Stress - physiology Ribosomal Protein S6 Kinases, 70-kDa - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism Vertebrates: digestive system Xanthine - pharmacology Xanthine Oxidase - pharmacology
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