Management of glioma in Victoria (1998–2000): retrospective cohort study
Objective: To describe the management of and outcomes in a population‐based cohort of patients with newly diagnosed glioma. Design, setting and patients: Retrospective cohort study of patients with glioma newly diagnosed over the period 1998–2000 in Victoria. Patients were identified from the popula...
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| Veröffentlicht in: | Medical journal of Australia 2006-03, Vol.184 (6), p.270-273 |
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| creator | Rosenthal, Mark A Drummond, Katharine J Dally, Michael Murphy, Michael Cher, Lawrence Ashley, David Thursfield, Vicky Giles, Graham G |
| description | Objective: To describe the management of and outcomes in a population‐based cohort of patients with newly diagnosed glioma.
Design, setting and patients: Retrospective cohort study of patients with glioma newly diagnosed over the period 1998–2000 in Victoria. Patients were identified from the population‐based Victorian Cancer Registry (VCR). Doctors involved in managing the patients were surveyed by a questionnaire sent out in 2003. The cohort was followed until the end of 2004 to obtain at least 4 years’ follow‐up data on all patients.
Main outcome measures: Reported treatment, referral patterns and survival rates.
Results: Over the study period, 992 cases of glioma were identified; 828 completed surveys on eligible patients were obtained (response rate, 93%); 473 patients (57%) had glioblastoma multiforme (GBM); 105 patients (13%) diagnosed with “glioma” had had no histological confirmation. Complete macroscopic resection was performed in 209 patients (25%); 612 patients (74%) were referred for radiotherapy and 326 (54%) for chemotherapy; 39 (5%) were enrolled on a clinical trial. Median survival was 9.2 months for all patients and 7.4 months for patients with GBM.
Conclusions: This is the largest reported glioma management survey in the world to date. Much of the patient demographics and approach to treatment were as expected and represent a reasonable “standard of care”. However, there are some areas for improvement, including the absence of histological diagnosis in some patients, lack of multidisciplinary care, low clinical trial enrolment and poor use of ancillary services. |
| doi_str_mv | 10.5694/j.1326-5377.2006.tb00235.x |
| format | Article |
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Design, setting and patients: Retrospective cohort study of patients with glioma newly diagnosed over the period 1998–2000 in Victoria. Patients were identified from the population‐based Victorian Cancer Registry (VCR). Doctors involved in managing the patients were surveyed by a questionnaire sent out in 2003. The cohort was followed until the end of 2004 to obtain at least 4 years’ follow‐up data on all patients.
Main outcome measures: Reported treatment, referral patterns and survival rates.
Results: Over the study period, 992 cases of glioma were identified; 828 completed surveys on eligible patients were obtained (response rate, 93%); 473 patients (57%) had glioblastoma multiforme (GBM); 105 patients (13%) diagnosed with “glioma” had had no histological confirmation. Complete macroscopic resection was performed in 209 patients (25%); 612 patients (74%) were referred for radiotherapy and 326 (54%) for chemotherapy; 39 (5%) were enrolled on a clinical trial. Median survival was 9.2 months for all patients and 7.4 months for patients with GBM.
Conclusions: This is the largest reported glioma management survey in the world to date. Much of the patient demographics and approach to treatment were as expected and represent a reasonable “standard of care”. However, there are some areas for improvement, including the absence of histological diagnosis in some patients, lack of multidisciplinary care, low clinical trial enrolment and poor use of ancillary services.</description><identifier>ISSN: 0025-729X</identifier><identifier>EISSN: 1326-5377</identifier><identifier>DOI: 10.5694/j.1326-5377.2006.tb00235.x</identifier><identifier>PMID: 16548830</identifier><identifier>CODEN: MJAUAJ</identifier><language>eng</language><publisher>Sydney: Australasian Medical Publishing Company</publisher><subject><![CDATA[Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Biopsy ; Biopsy - statistics & numerical data ; Cancer therapies ; Chemotherapy ; Clinical trials ; Cohort analysis ; Cohort Studies ; Combined Modality Therapy - statistics & numerical data ; Female ; Follow-Up Studies ; General aspects ; Glioma - pathology ; Glioma - therapy ; Health Care Surveys ; Humans ; Male ; Medical Oncology - statistics & numerical data ; Medical prognosis ; Medical sciences ; Middle Aged ; Neoplasms ; Nervous system diseases ; Neurology ; Outcome and Process Assessment, Health Care ; Pathology ; Patients ; Population ; Practice Patterns, Physicians' - statistics & numerical data ; Questionnaires ; Radiation therapy ; Radiotherapy - statistics & numerical data ; Referral and Consultation - statistics & numerical data ; Registries ; Retrospective Studies ; Statistical analysis ; Survival Analysis ; Tumors ; Tumors of the nervous system. Phacomatoses ; Victoria]]></subject><ispartof>Medical journal of Australia, 2006-03, Vol.184 (6), p.270-273</ispartof><rights>2006 AMPCo Pty Ltd. All rights reserved</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Australasian Medical Publishing Company Proprietary, Ltd. Mar 20, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4325-51ff6d4cbd094d2ed620aca5cbf2177d26f3021ea9f2c391a66ca25a09dff06e3</citedby><cites>FETCH-LOGICAL-c4325-51ff6d4cbd094d2ed620aca5cbf2177d26f3021ea9f2c391a66ca25a09dff06e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.5694%2Fj.1326-5377.2006.tb00235.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.5694%2Fj.1326-5377.2006.tb00235.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17626310$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16548830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenthal, Mark A</creatorcontrib><creatorcontrib>Drummond, Katharine J</creatorcontrib><creatorcontrib>Dally, Michael</creatorcontrib><creatorcontrib>Murphy, Michael</creatorcontrib><creatorcontrib>Cher, Lawrence</creatorcontrib><creatorcontrib>Ashley, David</creatorcontrib><creatorcontrib>Thursfield, Vicky</creatorcontrib><creatorcontrib>Giles, Graham G</creatorcontrib><title>Management of glioma in Victoria (1998–2000): retrospective cohort study</title><title>Medical journal of Australia</title><addtitle>Med J Aust</addtitle><description>Objective: To describe the management of and outcomes in a population‐based cohort of patients with newly diagnosed glioma.
Design, setting and patients: Retrospective cohort study of patients with glioma newly diagnosed over the period 1998–2000 in Victoria. Patients were identified from the population‐based Victorian Cancer Registry (VCR). Doctors involved in managing the patients were surveyed by a questionnaire sent out in 2003. The cohort was followed until the end of 2004 to obtain at least 4 years’ follow‐up data on all patients.
Main outcome measures: Reported treatment, referral patterns and survival rates.
Results: Over the study period, 992 cases of glioma were identified; 828 completed surveys on eligible patients were obtained (response rate, 93%); 473 patients (57%) had glioblastoma multiforme (GBM); 105 patients (13%) diagnosed with “glioma” had had no histological confirmation. Complete macroscopic resection was performed in 209 patients (25%); 612 patients (74%) were referred for radiotherapy and 326 (54%) for chemotherapy; 39 (5%) were enrolled on a clinical trial. Median survival was 9.2 months for all patients and 7.4 months for patients with GBM.
Conclusions: This is the largest reported glioma management survey in the world to date. Much of the patient demographics and approach to treatment were as expected and represent a reasonable “standard of care”. However, there are some areas for improvement, including the absence of histological diagnosis in some patients, lack of multidisciplinary care, low clinical trial enrolment and poor use of ancillary services.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Biopsy - statistics & numerical data</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Combined Modality Therapy - statistics & numerical data</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Glioma - pathology</subject><subject>Glioma - therapy</subject><subject>Health Care Surveys</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Oncology - statistics & numerical data</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms</subject><subject>Nervous system diseases</subject><subject>Neurology</subject><subject>Outcome and Process Assessment, Health Care</subject><subject>Pathology</subject><subject>Patients</subject><subject>Population</subject><subject>Practice Patterns, Physicians' - statistics & numerical data</subject><subject>Questionnaires</subject><subject>Radiation therapy</subject><subject>Radiotherapy - statistics & numerical data</subject><subject>Referral and Consultation - statistics & numerical data</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Victoria</subject><issn>0025-729X</issn><issn>1326-5377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtKxDAUhoMoOl5eQYqg6GJqLk0ydTeIVxQ3Ku5CJk00Q9uMSavOznfwDX0SU6couHOV23fO-fMBsINgSlmeHU5TRDAbUsJ5iiFkaTOBEBOavi2Bwc_TMhjEWzrkOH9YA-shTOMRUcxXwRpiNBuNCByAy2tZy0dd6bpJnEkeS-sqmdg6ubeqcd7KZB_l-ejz_SNOggdHideNd2GmVWNfdKLck_NNEpq2mG-CFSPLoLf6dQPcnZ7cHp8Pr27OLo7HV0OVkZiHImNYkalJAfOswLpgGEolqZoYjDgvMDMkBtUyN1iRHEnGlMRUwrwwBjJNNsDeou_Mu-dWh0ZUNihdlrLWrg2Ccc4R4VkEd_6AU9f6OmYT0RbPUEZIhI4WkIrfCl4bMfO2kn4uEBSdbjEVnVPRORWdbtHrFm-xeLuf0E4qXfyW9n4jsNsDMihZGi9rZcMvxxlmBHXceMG92lLP_xFBXF-O8feefAF2Y5xE</recordid><startdate>20060320</startdate><enddate>20060320</enddate><creator>Rosenthal, Mark A</creator><creator>Drummond, Katharine J</creator><creator>Dally, Michael</creator><creator>Murphy, Michael</creator><creator>Cher, Lawrence</creator><creator>Ashley, David</creator><creator>Thursfield, Vicky</creator><creator>Giles, Graham G</creator><general>Australasian Medical Publishing Company</general><general>Australasian Medical Publishing Company Proprietary, Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20060320</creationdate><title>Management of glioma in Victoria (1998–2000): retrospective cohort study</title><author>Rosenthal, Mark A ; Drummond, Katharine J ; Dally, Michael ; Murphy, Michael ; Cher, Lawrence ; Ashley, David ; Thursfield, Vicky ; Giles, Graham G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4325-51ff6d4cbd094d2ed620aca5cbf2177d26f3021ea9f2c391a66ca25a09dff06e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Biopsy - statistics & numerical data</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Combined Modality Therapy - statistics & numerical data</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Glioma - pathology</topic><topic>Glioma - therapy</topic><topic>Health Care Surveys</topic><topic>Humans</topic><topic>Male</topic><topic>Medical Oncology - statistics & numerical data</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms</topic><topic>Nervous system diseases</topic><topic>Neurology</topic><topic>Outcome and Process Assessment, Health Care</topic><topic>Pathology</topic><topic>Patients</topic><topic>Population</topic><topic>Practice Patterns, Physicians' - statistics & numerical data</topic><topic>Questionnaires</topic><topic>Radiation therapy</topic><topic>Radiotherapy - statistics & numerical data</topic><topic>Referral and Consultation - statistics & numerical data</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Victoria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenthal, Mark A</creatorcontrib><creatorcontrib>Drummond, Katharine J</creatorcontrib><creatorcontrib>Dally, Michael</creatorcontrib><creatorcontrib>Murphy, Michael</creatorcontrib><creatorcontrib>Cher, Lawrence</creatorcontrib><creatorcontrib>Ashley, David</creatorcontrib><creatorcontrib>Thursfield, Vicky</creatorcontrib><creatorcontrib>Giles, Graham G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Medical journal of Australia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenthal, Mark A</au><au>Drummond, Katharine J</au><au>Dally, Michael</au><au>Murphy, Michael</au><au>Cher, Lawrence</au><au>Ashley, David</au><au>Thursfield, Vicky</au><au>Giles, Graham G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of glioma in Victoria (1998–2000): retrospective cohort study</atitle><jtitle>Medical journal of Australia</jtitle><addtitle>Med J Aust</addtitle><date>2006-03-20</date><risdate>2006</risdate><volume>184</volume><issue>6</issue><spage>270</spage><epage>273</epage><pages>270-273</pages><issn>0025-729X</issn><eissn>1326-5377</eissn><coden>MJAUAJ</coden><abstract>Objective: To describe the management of and outcomes in a population‐based cohort of patients with newly diagnosed glioma.
Design, setting and patients: Retrospective cohort study of patients with glioma newly diagnosed over the period 1998–2000 in Victoria. Patients were identified from the population‐based Victorian Cancer Registry (VCR). Doctors involved in managing the patients were surveyed by a questionnaire sent out in 2003. The cohort was followed until the end of 2004 to obtain at least 4 years’ follow‐up data on all patients.
Main outcome measures: Reported treatment, referral patterns and survival rates.
Results: Over the study period, 992 cases of glioma were identified; 828 completed surveys on eligible patients were obtained (response rate, 93%); 473 patients (57%) had glioblastoma multiforme (GBM); 105 patients (13%) diagnosed with “glioma” had had no histological confirmation. Complete macroscopic resection was performed in 209 patients (25%); 612 patients (74%) were referred for radiotherapy and 326 (54%) for chemotherapy; 39 (5%) were enrolled on a clinical trial. Median survival was 9.2 months for all patients and 7.4 months for patients with GBM.
Conclusions: This is the largest reported glioma management survey in the world to date. Much of the patient demographics and approach to treatment were as expected and represent a reasonable “standard of care”. However, there are some areas for improvement, including the absence of histological diagnosis in some patients, lack of multidisciplinary care, low clinical trial enrolment and poor use of ancillary services.</abstract><cop>Sydney</cop><pub>Australasian Medical Publishing Company</pub><pmid>16548830</pmid><doi>10.5694/j.1326-5377.2006.tb00235.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Age Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Biological and medical sciences Biopsy Biopsy - statistics & numerical data Cancer therapies Chemotherapy Clinical trials Cohort analysis Cohort Studies Combined Modality Therapy - statistics & numerical data Female Follow-Up Studies General aspects Glioma - pathology Glioma - therapy Health Care Surveys Humans Male Medical Oncology - statistics & numerical data Medical prognosis Medical sciences Middle Aged Neoplasms Nervous system diseases Neurology Outcome and Process Assessment, Health Care Pathology Patients Population Practice Patterns, Physicians' - statistics & numerical data Questionnaires Radiation therapy Radiotherapy - statistics & numerical data Referral and Consultation - statistics & numerical data Registries Retrospective Studies Statistical analysis Survival Analysis Tumors Tumors of the nervous system. Phacomatoses Victoria |
| title | Management of glioma in Victoria (1998–2000): retrospective cohort study |
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