On the influence of oxygen and cell concentration in an SFPR whole cell biocatalytic Baeyer-Villiger oxidation process
Efficient whole cell biotransformations, in particular microbial whole cell Baeyer–Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The inte...
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| Veröffentlicht in: | Biotechnology and bioengineering 2006-04, Vol.93 (6), p.1138-1144 |
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| container_title | Biotechnology and bioengineering |
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| creator | Hilker, Iris Baldwin, Chris Alphand, Véronique Furstoss, Roland Woodley, John Wohlgemuth, Roland |
| description | Efficient whole cell biotransformations, in particular microbial whole cell Baeyer–Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer–Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. © 2006 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/bit.20829 |
| format | Article |
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Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer–Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. © 2006 Wiley Periodicals, Inc.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.20829</identifier><identifier>PMID: 16444739</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Baeyer-Villiger oxidation ; Bioconversions. 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Bioeng</addtitle><description>Efficient whole cell biotransformations, in particular microbial whole cell Baeyer–Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer–Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. © 2006 Wiley Periodicals, Inc.</description><subject>Baeyer-Villiger oxidation</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Bioreactors - microbiology</subject><subject>Biotechnology</subject><subject>Biotransformation</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - metabolism</subject><subject>Cell Division</subject><subject>Cells</subject><subject>cyclohexanone monooxygenase</subject><subject>Escherichia coli - cytology</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - metabolism</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>in situ SFPR</subject><subject>Ketones - metabolism</subject><subject>Kinetics</subject><subject>Lactones - metabolism</subject><subject>Methods. Procedures. Technologies</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Oxygen</subject><subject>Oxygen - analysis</subject><subject>Oxygen - metabolism</subject><subject>oxygen transfer</subject><subject>Oxygenases - genetics</subject><subject>Oxygenases - metabolism</subject><subject>oxygenation</subject><subject>Partial Pressure</subject><subject>whole cell biotransformation</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EosvCgT-AIiSQOKQd27GdHNlCtxUVRVBA6sVynEnr4k2KndDm3-OShUpICPlgWfPNvHl-hDylsEsB2F7thl0GJavukQWFSuXAKrhPFgAgcy4qtkMexXiZnqqU8iHZobIoCsWrBflx0mXDBWaua_2IncWsb7P-ZjrHLjNdk1n0PrN9KnRDMIPru4SmSvbp4MPH7Pqi9zgzteutGYyfBmezlcEJQ_7Fee_OMaSBrpmbr0JvMcbH5EFrfMQn23tJPh-8Pd0_zI9P1kf7r49zW5SyymtWCGgApeTCMAsFtYxxgbwBWiHUlNdIS2OFaZgUAkSVzNqStyCKhinJl-TlPDfpfh8xDnrj4u2-psN-jFoqpSgH9V-QAee8SGdJnv8FXvZj6JIJzShPkiyhS_JqhmzoYwzY6qvgNiZMmoK-jUynyPSvyBL7bDtwrDfY3JHbjBLwYguYaI1vg-msi3eckkomD4nbm7lr53H6t6JeHZ3-ls7nDhcHvPnTYcK39DFcCf31_VqfwbvVm7PDtRb8J5h3usg</recordid><startdate>20060420</startdate><enddate>20060420</enddate><creator>Hilker, Iris</creator><creator>Baldwin, Chris</creator><creator>Alphand, Véronique</creator><creator>Furstoss, Roland</creator><creator>Woodley, John</creator><creator>Wohlgemuth, Roland</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060420</creationdate><title>On the influence of oxygen and cell concentration in an SFPR whole cell biocatalytic Baeyer-Villiger oxidation process</title><author>Hilker, Iris ; Baldwin, Chris ; Alphand, Véronique ; Furstoss, Roland ; Woodley, John ; Wohlgemuth, Roland</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4869-b2450d0e6635a2c041c2235e3d019e0b13be18ac5ad2655059592c83f054d2763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Baeyer-Villiger oxidation</topic><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Bioreactors - microbiology</topic><topic>Biotechnology</topic><topic>Biotransformation</topic><topic>Bridged Bicyclo Compounds, Heterocyclic - metabolism</topic><topic>Cell Division</topic><topic>Cells</topic><topic>cyclohexanone monooxygenase</topic><topic>Escherichia coli - cytology</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - metabolism</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>in situ SFPR</topic><topic>Ketones - metabolism</topic><topic>Kinetics</topic><topic>Lactones - metabolism</topic><topic>Methods. Procedures. 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Bioeng</addtitle><date>2006-04-20</date><risdate>2006</risdate><volume>93</volume><issue>6</issue><spage>1138</spage><epage>1144</epage><pages>1138-1144</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>Efficient whole cell biotransformations, in particular microbial whole cell Baeyer–Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer–Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. © 2006 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16444739</pmid><doi>10.1002/bit.20829</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biotechnology and bioengineering, 2006-04, Vol.93 (6), p.1138-1144 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Baeyer-Villiger oxidation Bioconversions. Hemisynthesis Biological and medical sciences Bioreactors - microbiology Biotechnology Biotransformation Bridged Bicyclo Compounds, Heterocyclic - metabolism Cell Division Cells cyclohexanone monooxygenase Escherichia coli - cytology Escherichia coli - genetics Escherichia coli - metabolism Fermentation Fundamental and applied biological sciences. Psychology in situ SFPR Ketones - metabolism Kinetics Lactones - metabolism Methods. Procedures. Technologies Oxidation Oxidation-Reduction Oxygen Oxygen - analysis Oxygen - metabolism oxygen transfer Oxygenases - genetics Oxygenases - metabolism oxygenation Partial Pressure whole cell biotransformation |
| title | On the influence of oxygen and cell concentration in an SFPR whole cell biocatalytic Baeyer-Villiger oxidation process |
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