Surfactant pretreatment ameliorates ischemia-reperfusion injury of the lung

Objective: To investigate whether surfactant pretreatment provides lung protection in an animal model of lung ischemia-reperfusion injury (LIRI). Methods: Male Sprague–Dawley rats (n=100) were randomised to receive intratracheally administered surfactant or no pretreatment. One hour thereafter, anim...

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Veröffentlicht in:	European journal of cardio-thoracic surgery 2005-05, Vol.27 (5), p.774-782
Hauptverfasser:	van der Kaaij, Niels P., Haitsma, Jack J., Kluin, Jolanda, Lambrecht, Bart N., Lachmann, Burkhard, de Bruin, Ron W.F., Bogers, Ad J.J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bronchoalveolar Lavage Fluid - chemistry Flow Cytometry Ischemia-reperfusion injury Lung Lung - drug effects Lung - physiopathology Lung Compliance Male Models, Animal Phospholipids - analysis Proteins - analysis Pulmonary surfactant Pulmonary Surfactants - therapeutic use Random Allocation Rats Rats, Sprague-Dawley Reperfusion Injury - prevention & control
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