Drug transporters in pharmacokinetics
This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 2006-03, Vol.372 (6), p.465-475 |
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| container_end_page | 475 |
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| container_issue | 6 |
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| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
| container_volume | 372 |
| creator | Petzinger, Ernst Geyer, Joachim |
| description | This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms yielding functional carrier protein mutations. An integrated phase concept should reflect the interplay between drug metabolism and drug transport. |
| doi_str_mv | 10.1007/s00210-006-0042-9 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2006-03, Vol.372 (6), p.465-475 |
| issn | 0028-1298 1432-1912 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67769731 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological Transport Blood-Brain Barrier - metabolism Humans Kidney - metabolism Liver - metabolism Membrane Transport Proteins - chemistry Membrane Transport Proteins - metabolism Models, Biological Pharmaceutical Preparations - metabolism Xenobiotics - metabolism Xenobiotics - pharmacokinetics |
| title | Drug transporters in pharmacokinetics |
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