An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin
An efficient method was developed for the preparation of polyanionic affinity agent ( 3) and its application in the measurement of glycated hemoglobin was evaluated. An efficient method was developed for the preparation of polyanionic affinity agent ( 3), a key component in the measurement of glycat...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2005-05, Vol.13 (10), p.3467-3473 |
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| creator | Reddy, Rajarathnam E. Pan, You Johnson, Donald D. Chen, Yon-Yih Datwyler, Saul A. Hauptman, Michelle S. Thottathil, John K. |
| description | An efficient method was developed for the preparation of polyanionic affinity agent (
3) and its application in the measurement of glycated hemoglobin was evaluated.
An efficient method was developed for the preparation of polyanionic affinity agent (
3), a key component in the measurement of glycated hemoglobin (GHb). Glycated hemoglobin is an important clinical marker for diagnosis of patients with diabetes and useful to monitor the management of disease. The affinity agent (
3) was prepared based on coupling reaction between poly(acrylic acid) (
1) and 3-aminophenylboronic acid (
2) in water. The critical features of this polymeric affinity agent (
3), such as size, boronic acid incorporation ratio and concentration, on the measurement of glycated hemoglobin were evaluated. It was found that the agent (
3) prepared using poly(acrylic acid) (
1) with 225
kDa molecular weight gave optimal GHb measurement. The performance test results demonstrated that the boronic acid incorporation ratio and concentration of affinity agent (
3) play a critical role in the assay and determines the precision of glycated hemoglobin measurement. |
| doi_str_mv | 10.1016/j.bmc.2005.02.058 |
| format | Article |
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3) and its application in the measurement of glycated hemoglobin was evaluated.
An efficient method was developed for the preparation of polyanionic affinity agent (
3), a key component in the measurement of glycated hemoglobin (GHb). Glycated hemoglobin is an important clinical marker for diagnosis of patients with diabetes and useful to monitor the management of disease. The affinity agent (
3) was prepared based on coupling reaction between poly(acrylic acid) (
1) and 3-aminophenylboronic acid (
2) in water. The critical features of this polymeric affinity agent (
3), such as size, boronic acid incorporation ratio and concentration, on the measurement of glycated hemoglobin were evaluated. It was found that the agent (
3) prepared using poly(acrylic acid) (
1) with 225
kDa molecular weight gave optimal GHb measurement. The performance test results demonstrated that the boronic acid incorporation ratio and concentration of affinity agent (
3) play a critical role in the assay and determines the precision of glycated hemoglobin measurement.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2005.02.058</identifier><identifier>PMID: 15848760</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acrylic Resins - chemical synthesis ; Acrylic Resins - chemistry ; Acrylic Resins - metabolism ; Biological and medical sciences ; Boronic Acids - chemical synthesis ; Boronic Acids - chemistry ; Boronic Acids - metabolism ; Chromatography, Affinity ; Diabetes mellitus ; Endocrinology ; Evaluation Studies as Topic ; Glycated hemoglobin ; Glycated Hemoglobin A - analysis ; Glycated Hemoglobin A - metabolism ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Polyanionic affinity agent</subject><ispartof>Bioorganic & medicinal chemistry, 2005-05, Vol.13 (10), p.3467-3473</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-7f1d3e2eb578d3a6c32459dac0a21645256f1eb36fbabc9b685b42080d9bc5263</citedby><cites>FETCH-LOGICAL-c381t-7f1d3e2eb578d3a6c32459dac0a21645256f1eb36fbabc9b685b42080d9bc5263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmc.2005.02.058$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16742159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15848760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reddy, Rajarathnam E.</creatorcontrib><creatorcontrib>Pan, You</creatorcontrib><creatorcontrib>Johnson, Donald D.</creatorcontrib><creatorcontrib>Chen, Yon-Yih</creatorcontrib><creatorcontrib>Datwyler, Saul A.</creatorcontrib><creatorcontrib>Hauptman, Michelle S.</creatorcontrib><creatorcontrib>Thottathil, John K.</creatorcontrib><title>An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>An efficient method was developed for the preparation of polyanionic affinity agent (
3) and its application in the measurement of glycated hemoglobin was evaluated.
An efficient method was developed for the preparation of polyanionic affinity agent (
3), a key component in the measurement of glycated hemoglobin (GHb). Glycated hemoglobin is an important clinical marker for diagnosis of patients with diabetes and useful to monitor the management of disease. The affinity agent (
3) was prepared based on coupling reaction between poly(acrylic acid) (
1) and 3-aminophenylboronic acid (
2) in water. The critical features of this polymeric affinity agent (
3), such as size, boronic acid incorporation ratio and concentration, on the measurement of glycated hemoglobin were evaluated. It was found that the agent (
3) prepared using poly(acrylic acid) (
1) with 225
kDa molecular weight gave optimal GHb measurement. The performance test results demonstrated that the boronic acid incorporation ratio and concentration of affinity agent (
3) play a critical role in the assay and determines the precision of glycated hemoglobin measurement.</description><subject>Acrylic Resins - chemical synthesis</subject><subject>Acrylic Resins - chemistry</subject><subject>Acrylic Resins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Boronic Acids - chemical synthesis</subject><subject>Boronic Acids - chemistry</subject><subject>Boronic Acids - metabolism</subject><subject>Chromatography, Affinity</subject><subject>Diabetes mellitus</subject><subject>Endocrinology</subject><subject>Evaluation Studies as Topic</subject><subject>Glycated hemoglobin</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Polyanionic affinity agent</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMoznX0B7iRbHTXmqRJmuJqGPyCATe6Dkl6cieXtqlJOnD_vSn3wuxcHQ4878vhOQi9p6SlhMrPp9bOrmWEiJawlgj1Ah0ol7zpuoG-RAcySNUQNcgb9CbnEyGE8YG-RjdUKK56SQ6o3C0YvA8uwFLwmmA1yZQQFxw9XuN0NktdgsOmQksoZ2yOO2mWEYeSMTyZabsEfEy4PAKeweQtwbxjteQ4nZ0pMOJHmONxijYsb9Erb6YM767zFv359vX3_Y_m4df3n_d3D43rFC1N7-nYAQMrejV2RrqOcTGMxhHDqOSCCekp2E56a6wbrFTCckYUGQfrBJPdLfp06V1T_LtBLnoO2cE0mQXilrXsezlwTipIL6BLMecEXq8pzCadNSV6V61PuqrWu2pNmK6qa-bDtXyzM4zPiavbCny8AiY7M_lkFhfyMyd7zqgYKvflwkFV8RQg6bx_w8EYEriixxj-c8Y_E2qd-A</recordid><startdate>20050516</startdate><enddate>20050516</enddate><creator>Reddy, Rajarathnam E.</creator><creator>Pan, You</creator><creator>Johnson, Donald D.</creator><creator>Chen, Yon-Yih</creator><creator>Datwyler, Saul A.</creator><creator>Hauptman, Michelle S.</creator><creator>Thottathil, John K.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050516</creationdate><title>An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin</title><author>Reddy, Rajarathnam E. ; Pan, You ; Johnson, Donald D. ; Chen, Yon-Yih ; Datwyler, Saul A. ; Hauptman, Michelle S. ; Thottathil, John K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-7f1d3e2eb578d3a6c32459dac0a21645256f1eb36fbabc9b685b42080d9bc5263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acrylic Resins - chemical synthesis</topic><topic>Acrylic Resins - chemistry</topic><topic>Acrylic Resins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Boronic Acids - chemical synthesis</topic><topic>Boronic Acids - chemistry</topic><topic>Boronic Acids - metabolism</topic><topic>Chromatography, Affinity</topic><topic>Diabetes mellitus</topic><topic>Endocrinology</topic><topic>Evaluation Studies as Topic</topic><topic>Glycated hemoglobin</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Polyanionic affinity agent</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddy, Rajarathnam E.</creatorcontrib><creatorcontrib>Pan, You</creatorcontrib><creatorcontrib>Johnson, Donald D.</creatorcontrib><creatorcontrib>Chen, Yon-Yih</creatorcontrib><creatorcontrib>Datwyler, Saul A.</creatorcontrib><creatorcontrib>Hauptman, Michelle S.</creatorcontrib><creatorcontrib>Thottathil, John K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddy, Rajarathnam E.</au><au>Pan, You</au><au>Johnson, Donald D.</au><au>Chen, Yon-Yih</au><au>Datwyler, Saul A.</au><au>Hauptman, Michelle S.</au><au>Thottathil, John K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2005-05-16</date><risdate>2005</risdate><volume>13</volume><issue>10</issue><spage>3467</spage><epage>3473</epage><pages>3467-3473</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>An efficient method was developed for the preparation of polyanionic affinity agent (
3) and its application in the measurement of glycated hemoglobin was evaluated.
An efficient method was developed for the preparation of polyanionic affinity agent (
3), a key component in the measurement of glycated hemoglobin (GHb). Glycated hemoglobin is an important clinical marker for diagnosis of patients with diabetes and useful to monitor the management of disease. The affinity agent (
3) was prepared based on coupling reaction between poly(acrylic acid) (
1) and 3-aminophenylboronic acid (
2) in water. The critical features of this polymeric affinity agent (
3), such as size, boronic acid incorporation ratio and concentration, on the measurement of glycated hemoglobin were evaluated. It was found that the agent (
3) prepared using poly(acrylic acid) (
1) with 225
kDa molecular weight gave optimal GHb measurement. The performance test results demonstrated that the boronic acid incorporation ratio and concentration of affinity agent (
3) play a critical role in the assay and determines the precision of glycated hemoglobin measurement.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15848760</pmid><doi>10.1016/j.bmc.2005.02.058</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Bioorganic & medicinal chemistry, 2005-05, Vol.13 (10), p.3467-3473 |
| issn | 0968-0896 1464-3391 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acrylic Resins - chemical synthesis Acrylic Resins - chemistry Acrylic Resins - metabolism Biological and medical sciences Boronic Acids - chemical synthesis Boronic Acids - chemistry Boronic Acids - metabolism Chromatography, Affinity Diabetes mellitus Endocrinology Evaluation Studies as Topic Glycated hemoglobin Glycated Hemoglobin A - analysis Glycated Hemoglobin A - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polyanionic affinity agent |
| title | An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin |
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