An Isoform of GTPase Regulator DOCK4 Localizes to the Stereocilia in the Inner Ear and Binds to Harmonin (USH1C)

The driving forces for the regulation of cell morphology are the Rho family GTPases that coordinate the assembly of the actin cytoskeleton. This dynamic feature is a result of tight coupling between the cytoskeleton and signal transduction and is facilitated by actin-binding proteins (ABPs). Mutatio...

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Veröffentlicht in:	Journal of molecular biology 2006-03, Vol.357 (3), p.755-764
Hauptverfasser:	Yan, D., Li, F., Hall, M.L., Sage, C., Hu, W.-H., Giallourakis, Cosmas, Upadhyay, G., Ouyang, X.M., Du, L.L., Bethea, John R., Chen, Z.Y., Yajnik, V., Liu, X.Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin bundling protein Actins - metabolism Adaptor Proteins, Signal Transducing - metabolism Animals Carrier Proteins - metabolism Cell Line Cilia - enzymology Cilia - metabolism Cytoskeleton - metabolism DOCK4 Ear, Inner - enzymology Ear, Inner - metabolism Exons GTPase regulator GTPase-Activating Proteins - immunology GTPase-Activating Proteins - metabolism Guanine Nucleotide Exchange Factors - metabolism harmonin Humans Mice Protein Isoforms - metabolism rac GTP-Binding Proteins - metabolism rho GTP-Binding Proteins - metabolism Signal Transduction - physiology Two-Hybrid System Techniques
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