Intrathecal antibody production in a mouse model of Lyme neuroborreliosis
Intrathecal antibody (ITAb) production is a common feature of neurological diseases, yet very little is known about its mechanisms. Because ITAb is prominent in human Lyme neuroborreliosis (LNB), in the present study we established a mouse model of LNB to study ITAb production. We injected different...
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| Veröffentlicht in: | Journal of neuroimmunology 2006-04, Vol.173 (1), p.56-68 |
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| container_title | Journal of neuroimmunology |
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| creator | Li, Libin Narayan, Kavitha Pak, Elena Pachner, Andrew R. |
| description | Intrathecal antibody (ITAb) production is a common feature of neurological diseases, yet very little is known about its mechanisms. Because ITAb is prominent in human Lyme neuroborreliosis (LNB), in the present study we established a mouse model of LNB to study ITAb production.
We injected different strains of
Borrelia burgdorferi into a variety of mouse strains by the intracerebral (i.c.) route to develop the model. Spirochetal infection and ITAb production were identified by complementary methods. This study demonstrates that the mouse model of LNB can be utilized to test hypotheses related to the mechanisms of ITAb production. |
| doi_str_mv | 10.1016/j.jneuroim.2005.11.019 |
| format | Article |
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We injected different strains of
Borrelia burgdorferi into a variety of mouse strains by the intracerebral (i.c.) route to develop the model. Spirochetal infection and ITAb production were identified by complementary methods. This study demonstrates that the mouse model of LNB can be utilized to test hypotheses related to the mechanisms of ITAb production.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2005.11.019</identifier><identifier>PMID: 16387369</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antibodies, Bacterial - cerebrospinal fluid ; Antibody ; Antibody Formation ; Borrelia burgdorferi ; Borrelia burgdorferi - immunology ; Brain Diseases - immunology ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Immunoblotting ; Immunoglobulin G - cerebrospinal fluid ; Injections, Intraventricular ; Intrathecal ; Lyme ; Lyme Neuroborreliosis - immunology ; Male ; Mice ; Reverse Transcriptase Polymerase Chain Reaction</subject><ispartof>Journal of neuroimmunology, 2006-04, Vol.173 (1), p.56-68</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-d515179cecbb7e99bdd82e8026bbb87b2944b1a26a8ec3a6af697523b683ee153</citedby><cites>FETCH-LOGICAL-c463t-d515179cecbb7e99bdd82e8026bbb87b2944b1a26a8ec3a6af697523b683ee153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2005.11.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16387369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Libin</creatorcontrib><creatorcontrib>Narayan, Kavitha</creatorcontrib><creatorcontrib>Pak, Elena</creatorcontrib><creatorcontrib>Pachner, Andrew R.</creatorcontrib><title>Intrathecal antibody production in a mouse model of Lyme neuroborreliosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Intrathecal antibody (ITAb) production is a common feature of neurological diseases, yet very little is known about its mechanisms. Because ITAb is prominent in human Lyme neuroborreliosis (LNB), in the present study we established a mouse model of LNB to study ITAb production.
We injected different strains of
Borrelia burgdorferi into a variety of mouse strains by the intracerebral (i.c.) route to develop the model. Spirochetal infection and ITAb production were identified by complementary methods. This study demonstrates that the mouse model of LNB can be utilized to test hypotheses related to the mechanisms of ITAb production.</description><subject>Animals</subject><subject>Antibodies, Bacterial - cerebrospinal fluid</subject><subject>Antibody</subject><subject>Antibody Formation</subject><subject>Borrelia burgdorferi</subject><subject>Borrelia burgdorferi - immunology</subject><subject>Brain Diseases - immunology</subject><subject>Disease Models, Animal</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Immunoblotting</subject><subject>Immunoglobulin G - cerebrospinal fluid</subject><subject>Injections, Intraventricular</subject><subject>Intrathecal</subject><subject>Lyme</subject><subject>Lyme Neuroborreliosis - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu2zAQRYmiRew8fsHQqjspHEriY5ciaFoDBrpp1wQfY4SGJDqkVMB_X7p20WU2M5szc2cOIRugDVDgj4fmMOGSYhgbRmnfADQU1AeyBilYLTsGH8m6gH3dCyZX5DbnA6XQt526ISvgrRQtV2uy3U5zMvMrOjNUZpqDjf5UHVP0i5tDnKowVaYa45KxVI9DFffV7jRi9TfexpRwCDGHfE8-7c2Q8eHa78ivl68_n7_Xux_fts9fdrXreDvXvocehHLorBWolPVeMpSUcWutFJaprrNgGDcSXWu42XMletZaLlvE8sAd-XzZW458WzDPegzZ4TCYCcuZmgvBFW3fB0GpXnCqCsgvoEsx54R7fUxhNOmkgeqzbX3Q_2zrs20NoIvtMri5Jix2RP9_7Kq3AE8XAIuQ3wGTzi7g5NCHhG7WPob3Mv4AI-uVWw</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Li, Libin</creator><creator>Narayan, Kavitha</creator><creator>Pak, Elena</creator><creator>Pachner, Andrew R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TK</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Intrathecal antibody production in a mouse model of Lyme neuroborreliosis</title><author>Li, Libin ; Narayan, Kavitha ; Pak, Elena ; Pachner, Andrew R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-d515179cecbb7e99bdd82e8026bbb87b2944b1a26a8ec3a6af697523b683ee153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - cerebrospinal fluid</topic><topic>Antibody</topic><topic>Antibody Formation</topic><topic>Borrelia burgdorferi</topic><topic>Borrelia burgdorferi - immunology</topic><topic>Brain Diseases - immunology</topic><topic>Disease Models, Animal</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Immunoblotting</topic><topic>Immunoglobulin G - cerebrospinal fluid</topic><topic>Injections, Intraventricular</topic><topic>Intrathecal</topic><topic>Lyme</topic><topic>Lyme Neuroborreliosis - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Libin</creatorcontrib><creatorcontrib>Narayan, Kavitha</creatorcontrib><creatorcontrib>Pak, Elena</creatorcontrib><creatorcontrib>Pachner, Andrew R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Libin</au><au>Narayan, Kavitha</au><au>Pak, Elena</au><au>Pachner, Andrew R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal antibody production in a mouse model of Lyme neuroborreliosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>173</volume><issue>1</issue><spage>56</spage><epage>68</epage><pages>56-68</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Intrathecal antibody (ITAb) production is a common feature of neurological diseases, yet very little is known about its mechanisms. Because ITAb is prominent in human Lyme neuroborreliosis (LNB), in the present study we established a mouse model of LNB to study ITAb production.
We injected different strains of
Borrelia burgdorferi into a variety of mouse strains by the intracerebral (i.c.) route to develop the model. Spirochetal infection and ITAb production were identified by complementary methods. This study demonstrates that the mouse model of LNB can be utilized to test hypotheses related to the mechanisms of ITAb production.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16387369</pmid><doi>10.1016/j.jneuroim.2005.11.019</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 2006-04, Vol.173 (1), p.56-68 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antibodies, Bacterial - cerebrospinal fluid Antibody Antibody Formation Borrelia burgdorferi Borrelia burgdorferi - immunology Brain Diseases - immunology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Immunoblotting Immunoglobulin G - cerebrospinal fluid Injections, Intraventricular Intrathecal Lyme Lyme Neuroborreliosis - immunology Male Mice Reverse Transcriptase Polymerase Chain Reaction |
| title | Intrathecal antibody production in a mouse model of Lyme neuroborreliosis |
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