Different Osteogenic Potentials of Recombinant Human BMP-6 Adeno-Associated Virus and Adenovirus in Two Rat Strains

The osteogenic potential of AAV5hBMP6 was compared with that of ADhBMP6 in immunodeficient and immunocompetent rats. AAV5hBMP6 (2.3 × 10 12 particles) and ADhBMP6 (5 × 10 7 PFU) elicited viral antibody production in immunocompetent rats. Among rats that received AAV5hBMP6, the earliest time points a...

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Veröffentlicht in:	Tissue engineering 2006-02, Vol.12 (2), p.29-219
Hauptverfasser:	Li, Jin Zhong, Li, Hongwei, Hankins, Gerald R., Lieu, Ann-Shung, Noh, El, Jacobson, Lindsey, Pittman, Debra D., Chiorini, John A., Helm, Gregory A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adenoviridae - genetics Adenovirus Animals Bone Morphogenetic Protein 6 Bone Morphogenetic Proteins - administration & dosage Bone Morphogenetic Proteins - pharmacology Bones CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Dependovirus - genetics Genetic Vectors Humans Immunology Muscle, Skeletal - cytology Osteogenesis - drug effects Osteogenesis - physiology Rats Rats, Nude Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Rodents Species Specificity Time Factors Tissue engineering Tomography, X-Ray Viruses
Online-Zugang:	Volltext
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