Determination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography–atmospheric pressure chemical ionisation-mass spectrometry
A sensitive method for the determination and confirmation of the sum of malachite green (MG) and leucomalachite green (LMG) in salmon muscle has been developed. It is based on the use of an oxidative pre-column reaction which converts LMG into MG previous to liquid chromatography–atmospheric pressur...
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| Veröffentlicht in: | Journal of Chromatography A 2005-03, Vol.1067 (1), p.101-105 |
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| creator | Valle, Luis Díaz, Cecilia Zanocco, Antonio L. Richter, Pablo |
| description | A sensitive method for the determination and confirmation of the sum of malachite green (MG) and leucomalachite green (LMG) in salmon muscle has been developed. It is based on the use of an oxidative pre-column reaction which converts LMG into MG previous to liquid chromatography–atmospheric pressure chemical ionisation–mass spectrometry (LC–APCI–MS) analysis. The determination of both compounds together constitutes a good screening method to confirm the presence of this kind of residue, taking into account that the combined signals will provide a gain of sensitivity. The detection limit, determined for spiked salmon samples using the confirmatory ion
m/
z 313, was 0.15
μg/kg. The recoveries determined at a spiking level of 2
μg/kg were 85 and 70% for LMG and MG, respectively, with respective relative standard deviations of 1.3 and 3.1%. |
| doi_str_mv | 10.1016/j.chroma.2004.10.049 |
| format | Article |
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m/
z 313, was 0.15
μg/kg. The recoveries determined at a spiking level of 2
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m/
z 313, was 0.15
μg/kg. The recoveries determined at a spiking level of 2
μg/kg were 85 and 70% for LMG and MG, respectively, with respective relative standard deviations of 1.3 and 3.1%.</description><subject>Aniline Compounds - analysis</subject><subject>Animals</subject><subject>antifungal agents</subject><subject>Atmospheric Pressure</subject><subject>atmospheric pressure chemical ionization mass spectrometry</subject><subject>Chromatography, Liquid - methods</subject><subject>drug residues</subject><subject>farmed fish</subject><subject>fish fillets</subject><subject>food contamination</subject><subject>Leucomalachite green</subject><subject>liquid chromatography</subject><subject>Malachite green</subject><subject>mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Muscles - chemistry</subject><subject>Rosaniline Dyes - analysis</subject><subject>Salmon</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGO1DAQRbMAMcPADRB4xS5N2XHHyQYJDTAgjcQCZm05TqXbrTjOuByk3nEHjsGtOMm4SUtILFhVqfzq67t-UbzgsOHA6zeHjd3H4M1GAMg82oBsHxWXAIKXba2qi-Ip0QGAK1DiSXHBt42UWy4vi1_vMWH0bjLJhYmFgaU9Mlr8qfVmNHbvErJdRJyYmXo24mLDvw9uYmRGnwX8QnZE1h3Z6O4X17PVWAq7aOb98fePnyb5QPMeo7Nsjki0RMwUemfNyLIJR3-8lN4QMZrRpqyAKR6fFY8HMxI-P9er4u7jh2_Xn8rbLzefr9_dlrZqZCrtYJWthlpUUkCjAHkHLXLRN2poUSkwfZvBnldc8EbAtqux6upedpJjK2R1VbxedecY7hekpL0ji-NoJgwL6VqpupFbyKBcQRsDUcRBz9F5E4-agz4Fow96_b8-BXOa5mDy2suz_tJ57P8unVPJwKsVGEzQZhcd6buvAngF0DaqaUUm3q4E5jt8dxg1WYeTxd7FfDDdB_d_Dw_olbIQ</recordid><startdate>20050304</startdate><enddate>20050304</enddate><creator>Valle, Luis</creator><creator>Díaz, Cecilia</creator><creator>Zanocco, Antonio L.</creator><creator>Richter, Pablo</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050304</creationdate><title>Determination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography–atmospheric pressure chemical ionisation-mass spectrometry</title><author>Valle, Luis ; Díaz, Cecilia ; Zanocco, Antonio L. ; Richter, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-cfc7c3f623420870e1b09e12d87f9e770ad9384d131218205b6e3b6d4b41e9243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aniline Compounds - analysis</topic><topic>Animals</topic><topic>antifungal agents</topic><topic>Atmospheric Pressure</topic><topic>atmospheric pressure chemical ionization mass spectrometry</topic><topic>Chromatography, Liquid - methods</topic><topic>drug residues</topic><topic>farmed fish</topic><topic>fish fillets</topic><topic>food contamination</topic><topic>Leucomalachite green</topic><topic>liquid chromatography</topic><topic>Malachite green</topic><topic>mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Muscles - chemistry</topic><topic>Rosaniline Dyes - analysis</topic><topic>Salmon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valle, Luis</creatorcontrib><creatorcontrib>Díaz, Cecilia</creatorcontrib><creatorcontrib>Zanocco, Antonio L.</creatorcontrib><creatorcontrib>Richter, Pablo</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valle, Luis</au><au>Díaz, Cecilia</au><au>Zanocco, Antonio L.</au><au>Richter, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography–atmospheric pressure chemical ionisation-mass spectrometry</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2005-03-04</date><risdate>2005</risdate><volume>1067</volume><issue>1</issue><spage>101</spage><epage>105</epage><pages>101-105</pages><issn>0021-9673</issn><abstract>A sensitive method for the determination and confirmation of the sum of malachite green (MG) and leucomalachite green (LMG) in salmon muscle has been developed. It is based on the use of an oxidative pre-column reaction which converts LMG into MG previous to liquid chromatography–atmospheric pressure chemical ionisation–mass spectrometry (LC–APCI–MS) analysis. The determination of both compounds together constitutes a good screening method to confirm the presence of this kind of residue, taking into account that the combined signals will provide a gain of sensitivity. The detection limit, determined for spiked salmon samples using the confirmatory ion
m/
z 313, was 0.15
μg/kg. The recoveries determined at a spiking level of 2
μg/kg were 85 and 70% for LMG and MG, respectively, with respective relative standard deviations of 1.3 and 3.1%.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15844514</pmid><doi>10.1016/j.chroma.2004.10.049</doi><tpages>5</tpages></addata></record> |
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| subjects | Aniline Compounds - analysis Animals antifungal agents Atmospheric Pressure atmospheric pressure chemical ionization mass spectrometry Chromatography, Liquid - methods drug residues farmed fish fish fillets food contamination Leucomalachite green liquid chromatography Malachite green mass spectrometry Mass Spectrometry - methods Muscles - chemistry Rosaniline Dyes - analysis Salmon |
| title | Determination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography–atmospheric pressure chemical ionisation-mass spectrometry |
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