Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders

Major depressive disorder (MDD) is a common, clinically heterogeneous disorder often found comorbid with other disorders. We studied recurrent, early‐onset MDD (MDD‐RE) and anxiety disorders in combination to define powerful phenotypes for genetic study. We used 87 large, extended Utah pedigrees to...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2005-05, Vol.135B (1), p.85-93
Hauptverfasser:	Camp, Nicola J., Lowry, Michael R., Richards, R. Lynn, Plenk, Agnes M., Carter, Catherine, Hensel, Charles H., Abkevich, Victor, Skolnick, Mark H., Shattuck, Donna, Rowe, Kerry G., Hughes, Dana C., Cannon-Albright, Lisa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	anxiety Anxiety Disorders - genetics Anxiety Disorders - psychology Chromosomes, Human, Pair 18 - genetics Chromosomes, Human, Pair 3 - genetics Chromosomes, Human, Pair 7 - genetics comorbidity Depressive Disorder - genetics Depressive Disorder - psychology Family Health Female Genetic Linkage - genetics Genetic Predisposition to Disease - genetics Genome, Human Genotype Humans Lod Score Male Microsatellite Repeats Monte Carlo Markov chain neuroticism Pedigree Recurrence Sex Factors unipolar depression Utah
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