Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

Introduction of the post-transcriptional regulatory element (PRE) of woodchuck hepatitis virus (WHV) into the 3′ untranslated region of retroviral and lentiviral gene transfer vectors enhances both titer and transgene expression. Optimal use of the PRE is often necessary to obtain vectors with suffi...

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Veröffentlicht in:	Gene therapy 2006-04, Vol.13 (7), p.641-645
Hauptverfasser:	Schambach, A, Bohne, J, Baum, C, Hermann, F G, Egerer, L, von Laer, D, Giroglou, T
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cell Biology Chromosome deletion Expression vectors Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Gene Therapy Gene transfer Genes, Viral Genetic research Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - analysis Genetic Vectors - genetics Health aspects Health. Pharmaceutical industry Hepatitis Hepatocellular carcinoma Human Genetics Industrial applications and implications. Economical aspects Medical sciences Molecular and cellular biology Molecular genetics Nanotechnology Open Reading Frames Post-transcription Promoter Regions, Genetic Proteins Regulatory Sequences, Ribonucleic Acid Retroviridae - genetics RNA Processing, Post-Transcriptional short-communication Therapeutic applications Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Tumorigenesis Viral Proteins - genetics Woodchuck hepatitis virus
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