Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery
Selective androgen receptor modulators (SARMS) bind to the androgen receptor and demonstrate anabolic activity in a variety of tissues; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents are able to induce bone and muscle growth, as well as shrinking the prostate. Th...
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| Veröffentlicht in: | Expert opinion on investigational drugs 2006-04, Vol.15 (4), p.377-387 |
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| container_title | Expert opinion on investigational drugs |
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| creator | Segal, Scott Narayanan, Ramesh Dalton, James T |
| description | Selective androgen receptor modulators (SARMS) bind to the androgen receptor and demonstrate anabolic activity in a variety of tissues; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents are able to induce bone and muscle growth, as well as shrinking the prostate. The potential of SARMS is to maximise the positive attributes of steroidal androgens as well as minimising negative effects, thus providing therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, end-stage renal disease, osteoporosis, frailty and hypogonadism. This review summarises androgen physiolology, the current status of the R&D of SARMS and potential therapeutic indications for this emerging class of drugs. |
| doi_str_mv | 10.1517/13543784.15.4.377 |
| format | Article |
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| ispartof | Expert opinion on investigational drugs, 2006-04, Vol.15 (4), p.377-387 |
| issn | 1354-3784 1744-7658 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | androgen Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Androgen Receptor Antagonists Androgens - pharmacology Androgens - therapeutic use Animals Drug Design Humans hypogonadism Male muscle wasting osteoporosis Receptors, Androgen - metabolism steroid |
| title | Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery |
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