Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3‐FKHR positive and negative tumors

We analyzed the expression signatures of 14 tumor biopsies from children affected by alveolar rhabdomyosarcoma (ARMS) to identify genes correlating to biological features of this tumor. Seven of these patients were positive for the PAX3‐FKHR fusion gene and 7 were negative. We used a cDNA platform c...

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Veröffentlicht in:	International journal of cancer 2006-06, Vol.118 (11), p.2772-2781
Hauptverfasser:	De Pittà, Cristiano, Tombolan, Lucia, Albiero, Giada, Sartori, Francesca, Romualdi, Chiara, Jurman, Giuseppe, Carli, Modesto, Furlanello, Cesare, Lanfranchi, Gerolamo, Rosolen, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent alveolar rhabdomyosarcoma Biological and medical sciences Child Child, Preschool Diseases of the osteoarticular system Female Forkhead Box Protein O1 Forkhead Transcription Factors - analysis Forkhead Transcription Factors - genetics Gene Expression Profiling Humans Infant Male Medical sciences microarray Oligonucleotide Array Sequence Analysis Paired Box Transcription Factors - analysis Paired Box Transcription Factors - genetics PAX3 Transcription Factor PAX3‐FKHR Prognosis Reverse Transcriptase Polymerase Chain Reaction Rhabdomyosarcoma, Alveolar - genetics Rhabdomyosarcoma, Alveolar - physiopathology Tumors Tumors of striated muscle and skeleton
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