The Psammaplysenes, Specific Inhibitors of FOXO1a Nuclear Export
A small collection of marine natural product extracts was screened for compounds that would compensate lost tumor suppressor functionality in PTEN-deficient cells. From the most active extract, the previously unreported bromotyrosine derivative, psammaplysene A (1), was identified. Psammaplysene A c...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2005-04, Vol.68 (4), p.574-576 |
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| container_end_page | 576 |
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| container_issue | 4 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 68 |
| creator | Schroeder, Frank C Kau, Tweeny R Silver, Pamela A Clardy, Jon |
| description | A small collection of marine natural product extracts was screened for compounds that would compensate lost tumor suppressor functionality in PTEN-deficient cells. From the most active extract, the previously unreported bromotyrosine derivative, psammaplysene A (1), was identified. Psammaplysene A compensates for PTEN loss by relocalizing the transcription factor FOXO1a to the nucleus. |
| doi_str_mv | 10.1021/np049624z |
| format | Article |
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Drug treatments ; Phosphoric Monoester Hydrolases - deficiency ; Phosphoric Monoester Hydrolases - genetics ; Porifera - chemistry ; PTEN Phosphohydrolase ; Transcription Factors - antagonists & inhibitors ; Tumor Suppressor Proteins - deficiency ; Tumor Suppressor Proteins - genetics ; Tyrosine - analogs & derivatives ; Tyrosine - chemistry ; Tyrosine - isolation & purification ; Tyrosine - pharmacology</subject><ispartof>Journal of natural products (Washington, D.C.), 2005-04, Vol.68 (4), p.574-576</ispartof><rights>Copyright © 2005 American Chemical Society and American Society of Pharmacognosy</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a381t-1fc57e9785850ed3c6247de08f54f155e58f11f15e6a5a86799305c39a78420b3</citedby><cites>FETCH-LOGICAL-a381t-1fc57e9785850ed3c6247de08f54f155e58f11f15e6a5a86799305c39a78420b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np049624z$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np049624z$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16724660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15844952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schroeder, Frank C</creatorcontrib><creatorcontrib>Kau, Tweeny R</creatorcontrib><creatorcontrib>Silver, Pamela A</creatorcontrib><creatorcontrib>Clardy, Jon</creatorcontrib><title>The Psammaplysenes, Specific Inhibitors of FOXO1a Nuclear Export</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>A small collection of marine natural product extracts was screened for compounds that would compensate lost tumor suppressor functionality in PTEN-deficient cells. From the most active extract, the previously unreported bromotyrosine derivative, psammaplysene A (1), was identified. Psammaplysene A compensates for PTEN loss by relocalizing the transcription factor FOXO1a to the nucleus.</description><subject>Active Transport, Cell Nucleus - drug effects</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>DNA-Binding Proteins - antagonists & inhibitors</subject><subject>Forkhead Box Protein O1</subject><subject>Forkhead Transcription Factors</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Indian Ocean</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphoric Monoester Hydrolases - deficiency</subject><subject>Phosphoric Monoester Hydrolases - genetics</subject><subject>Porifera - chemistry</subject><subject>PTEN Phosphohydrolase</subject><subject>Transcription Factors - antagonists & inhibitors</subject><subject>Tumor Suppressor Proteins - deficiency</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - chemistry</subject><subject>Tyrosine - isolation & purification</subject><subject>Tyrosine - pharmacology</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0EtLAzEUBeAgiq2PhX9AZqMgOJrH5DE7RWotiC20oruQpjd06rxMZsD66x1psRtXuZCPw-EgdEbwDcGU3JY1TlJBk-891Cec4lhgyvdRHxPBYqZE0kNHIawwxgyn_BD1CFdJknLaR3ezJUSTYIrC1Pk6QAnhOprWYDOX2WhULrN51lQ-RJWLHsfvY2Kil9bmYHw0-Kor35ygA2fyAKfb9xi9Pg5mD0_x83g4erh_jg1TpImJs1xCKhVXHMOC2a6uXABWjieOcA5cOUK6C4ThRgmZpgxzy1IjVULxnB2jy01u7avPFkKjiyxYyHNTQtUGLaQUIhWyg1cbaH0Vggena58Vxq81wfp3Lv03V2fPt6HtvIDFTm736cDFFphgTe68KW0Wdk5ImgiBOxdvXBYa-Pr7N_6jK8Yk17PJVA_JEx1SSfTbLtfYoFdV68tuu38K_gBLkIrS</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Schroeder, Frank C</creator><creator>Kau, Tweeny R</creator><creator>Silver, Pamela A</creator><creator>Clardy, Jon</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>The Psammaplysenes, Specific Inhibitors of FOXO1a Nuclear Export</title><author>Schroeder, Frank C ; Kau, Tweeny R ; Silver, Pamela A ; Clardy, Jon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a381t-1fc57e9785850ed3c6247de08f54f155e58f11f15e6a5a86799305c39a78420b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Active Transport, Cell Nucleus - drug effects</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>DNA-Binding Proteins - antagonists & inhibitors</topic><topic>Forkhead Box Protein O1</topic><topic>Forkhead Transcription Factors</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Indian Ocean</topic><topic>Medical sciences</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. 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Drug treatments</topic><topic>Phosphoric Monoester Hydrolases - deficiency</topic><topic>Phosphoric Monoester Hydrolases - genetics</topic><topic>Porifera - chemistry</topic><topic>PTEN Phosphohydrolase</topic><topic>Transcription Factors - antagonists & inhibitors</topic><topic>Tumor Suppressor Proteins - deficiency</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - chemistry</topic><topic>Tyrosine - isolation & purification</topic><topic>Tyrosine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeder, Frank C</creatorcontrib><creatorcontrib>Kau, Tweeny R</creatorcontrib><creatorcontrib>Silver, Pamela A</creatorcontrib><creatorcontrib>Clardy, Jon</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schroeder, Frank C</au><au>Kau, Tweeny R</au><au>Silver, Pamela A</au><au>Clardy, Jon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Psammaplysenes, Specific Inhibitors of FOXO1a Nuclear Export</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2005-04, Vol.68 (4), p.574-576 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Active Transport, Cell Nucleus - drug effects Animals Biological and medical sciences DNA-Binding Proteins - antagonists & inhibitors Forkhead Box Protein O1 Forkhead Transcription Factors General pharmacology Humans Indian Ocean Medical sciences Models, Molecular Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - genetics Porifera - chemistry PTEN Phosphohydrolase Transcription Factors - antagonists & inhibitors Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - isolation & purification Tyrosine - pharmacology |
| title | The Psammaplysenes, Specific Inhibitors of FOXO1a Nuclear Export |
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