Overexpression of IFN-Induced Protein 10 and Its Receptor CXCR3 in Myasthenia Gravis

Myasthenia gravis (MG) and its animal model, experimental autoimmune MG (EAMG), are autoimmune disorders in which the acetylcholine receptor (AChR) is the major autoantigen. Microarray technology was used to identify new potential drug targets for treatment of myasthenia that would reduce the need f...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-05, Vol.174 (9), p.5324-5331
Hauptverfasser:	Feferman, Tali, Maiti, Prasanta K, Berrih-Aknin, Sonia, Bismuth, Jacky, Bidault, Jocelyne, Fuchs, Sara, Souroujon, Miriam C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Cell Adhesion Molecules - biosynthesis Chemokine CXCL10 Chemokines, CXC - biosynthesis Chemokines, CXC - genetics Chemokines, CXC - metabolism Female Gene Expression Profiling - methods Humans Interferon-gamma - physiology Lymph Nodes - immunology Lymph Nodes - metabolism Male Middle Aged Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Myasthenia Gravis - genetics Myasthenia Gravis - immunology Myasthenia Gravis - pathology Myasthenia Gravis, Autoimmune, Experimental - genetics Myasthenia Gravis, Autoimmune, Experimental - immunology Myasthenia Gravis, Autoimmune, Experimental - prevention & control Oligonucleotide Array Sequence Analysis Protein Subunits - administration & dosage Protein Subunits - immunology Rats Rats, Inbred Lew Receptors, Chemokine - biosynthesis Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Receptors, CXCR3 Receptors, Nicotinic - administration & dosage Receptors, Nicotinic - immunology Up-Regulation - immunology
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