VRK1 Signaling Pathway in the Context of the Proliferation Phenotype in Head and Neck Squamous Cell Carcinoma

The vaccinia-related kinase (VRK) proteins are a new family with three members in the human kinome. The VRK1 protein phosphorylates several transcription factors and has been postulated to be involved in regulation of cell proliferation. In normal squamous epithelium, VRK1 is expressed in the prolif...

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Veröffentlicht in:	Molecular cancer research 2006-03, Vol.4 (3), p.177-185
Hauptverfasser:	Santos, Claudio R, Rodríguez-Pinilla, María, Vega, Francisco M, Rodríguez-Peralto, José L, Blanco, Sandra, Sevilla, Ana, Valbuena, Alberto, Hernández, Teresa, van Wijnen, André J, Li, Fengzhi, de Alava, Enrique, Sánchez-Céspedes, Montserrat, Lazo, Pedro A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology cdk2 Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Proliferation Cyclin-Dependent Kinase 2 - genetics E2F1 Transcription Factor - metabolism Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Humans Immunohistochemistry Inhibitor of Apoptosis Proteins Intracellular Signaling Peptides and Proteins Microtubule-Associated Proteins - genetics Neoplasm Proteins - genetics p53 Phenotype proliferation Promoter Regions, Genetic Protein-Serine-Threonine Kinases Proteins - analysis Proteins - metabolism Signal Transduction survivin Tumor Suppressor Protein p53 - metabolism VRK1
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