Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine

We report the first safety and immunogenicity trial of the Plasmodium falciparum malaria blood stage vaccine candidate, FMP1/AS02A consisting of the FMP1 antigen, an Escherichia coli-expressed His-tagged fusion protein from the 42 kDa C-terminal fragment from the 3D7 clone of the merozoite surface p...

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Veröffentlicht in:	Vaccine 2006-04, Vol.24 (15), p.3009-3017
Hauptverfasser:	Ockenhouse, Christian F., Angov, Evelina, Kester, Kent E., Diggs, Carter, Soisson, Lorraine, Cummings, James F., Stewart, Ann V., Palmer, Dupeh R., Mahajan, Babita, Krzych, Urszula, Tornieporth, Nadia, Delchambre, M., Vanhandenhove, M., Ofori-Anyinam, Opokua, Cohen, Joe, Lyon, Jeffrey A., Heppner, D. Gray
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Adolescent Adult Animals Antibodies, Protozoan - blood Applied microbiology Biological and medical sciences Drug Combinations Enzyme-Linked Immunosorbent Assay Escherichia Escherichia coli Female Fluorescent Antibody Technique, Indirect FMP1/AS02A Fundamental and applied biological sciences. Psychology Humans Interferon-gamma - biosynthesis L-Lactate Dehydrogenase - analysis Lipid A - administration & dosage Lipid A - analogs & derivatives Lipid A - pharmacology Malaria Malaria Vaccines - administration & dosage Malaria Vaccines - adverse effects Malaria Vaccines - immunology Male Merozoite surface protein 1 Merozoite Surface Protein 1 - immunology Microbiology Middle Aged Plasmodium falciparum Plasmodium falciparum - growth & development Plasmodium falciparum - immunology Saponins - administration & dosage Saponins - pharmacology T-Lymphocytes - immunology Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - administration & dosage Vaccines, Subunit - adverse effects Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology
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