Foxc2 Is a Common Mediator of Insulin and Transforming Growth Factor β Signaling to Regulate Plasminogen Activator Inhibitor Type I Gene Expression

Elevated plasma levels of plasminogen activator inhibitor type I (PAI-1), a significant risk factor of ischemic heart disease, are associated with insulin resistance in which insulin and transforming growth factor (TGF)-β play a pivotal role in regulating PAI-1 production. Forkhead transcription fac...

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Veröffentlicht in:	Circulation research 2006-03, Vol.98 (5), p.626-634
Hauptverfasser:	Fujita, Hideo, Kang, Myengmo, Eren, Mesut, Gleaves, Linda A, Vaughan, Douglas E, Kume, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Cattle Cells, Cultured Forkhead Box Protein O1 Forkhead Transcription Factors - physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Insulin Resistance Plasminogen Activator Inhibitor 1 - genetics Promoter Regions, Genetic Signal Transduction Transcription, Genetic Transforming Growth Factor beta - physiology Transforming Growth Factor beta1 Vertebrates: cardiovascular system
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