High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease
We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory in...
Gespeichert in:
| Veröffentlicht in: | Journal of tropical pediatrics (1980) 2005-04, Vol.51 (2), p.98-101 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 101 |
|---|---|
| container_issue | 2 |
| container_start_page | 98 |
| container_title | Journal of tropical pediatrics (1980) |
| container_volume | 51 |
| creator | Lee, Kyung-Yil Lee, Hyung-Shin Hong, Ja-Hyun Han, Ji-Whan Lee, Joon-Sung Whang, Kyung-Tai |
| description | We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory indices were performed three times: before IVIG treatment, 24 h after IVIG treatment, and 7 days after IVIG treatment. The white blood cell and neutrophil counts showed significant decreases 24 h and 7 days after IVIG administration. The erythrocyte sedimentation rate (ESR) increased significantly 24 h after IVIG, and the elevated level was sustained for 7 days. The levels of hemoglobin, albumin and inflammation-associated proteins, including C-reactive protein, decreased 24 h after IVIG treatment. Inflammation-associated proteins, except transferrin, decreased further to near normal levels after 7 days. On the other hand, IgM and IgA were not affected after 24 h, rather increased significantly after 7 days. High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD. |
| doi_str_mv | 10.1093/tropej/fmh087 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67762028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>860339781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-c22aecc0014c1c033f4248902879eaf4a28cd25fdf5b92d8bdfe9b6f4fb27eb93</originalsourceid><addsrcrecordid>eNpdkU1vEzEQhlcIREPLkSuykOC21Gt7v45pE5LQSEgFJMTF8nrHidNdO9jetPlH_EwcJWokTtZoHj3jmTdJ3mX4c4Zreh2c3cLmWvVrXJUvklHGijylRcFeJiOcMZIWlFYXyRvvNxhjUjH2OrnI8qIsaYlHyd-5Xq3T1npACxOc2IGxg0eLvh-MXXW2GTpt0MQ-GgeroRMBPAprQGMZ9C5WLVrCDjqPrIoC1Ym-F8G6fSxaLSM8fZKwDWjq9mHtrNwHQN-h1T2YIIK2Bt1HC4ozxnI49IJYwUF2Jx6FFw8aTbQH4eEqeaVE5-Ht6b1Mfn6Z_ridp8tvs8XteJlKRvKQSkIESInj6jKTmFLFCKvquHhZg1BMkEq2JFetypuatFXTKqibQjHVkBKaml4mn47erbN_BvCB99pL6DphIF6Gx8MVJOoi-OE_cGMHZ-LfOCGMsryqWITSIySd9d6B4lune-H2PMP8kB8_5seP-UX-_Uk6ND20Z_oUWAQ-ngDhpeiUE0Zqf-aKKs_qPDsP1j7A03NfuIe4AS1zPv_1m88ms6-kqG94Sf8BOyC4nQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>224345884</pqid></control><display><type>article</type><title>High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease</title><source>MEDLINE</source><source>Oxford Journals</source><creator>Lee, Kyung-Yil ; Lee, Hyung-Shin ; Hong, Ja-Hyun ; Han, Ji-Whan ; Lee, Joon-Sung ; Whang, Kyung-Tai</creator><creatorcontrib>Lee, Kyung-Yil ; Lee, Hyung-Shin ; Hong, Ja-Hyun ; Han, Ji-Whan ; Lee, Joon-Sung ; Whang, Kyung-Tai</creatorcontrib><description>We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory indices were performed three times: before IVIG treatment, 24 h after IVIG treatment, and 7 days after IVIG treatment. The white blood cell and neutrophil counts showed significant decreases 24 h and 7 days after IVIG administration. The erythrocyte sedimentation rate (ESR) increased significantly 24 h after IVIG, and the elevated level was sustained for 7 days. The levels of hemoglobin, albumin and inflammation-associated proteins, including C-reactive protein, decreased 24 h after IVIG treatment. Inflammation-associated proteins, except transferrin, decreased further to near normal levels after 7 days. On the other hand, IgM and IgA were not affected after 24 h, rather increased significantly after 7 days. High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmh087</identifier><identifier>PMID: 15677370</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acute Disease ; Biological and medical sciences ; Biomarkers - metabolism ; Blood Sedimentation ; Child ; Child, Preschool ; Down-Regulation ; Female ; General aspects ; Humans ; Immunoglobulins, Intravenous - administration & dosage ; Immunoglobulins, Intravenous - immunology ; Immunoproteins - metabolism ; Infant ; Inflammation - immunology ; Inflammation - metabolism ; Leukocyte Count ; Male ; Medical sciences ; Mucocutaneous Lymph Node Syndrome - immunology ; Mucocutaneous Lymph Node Syndrome - therapy ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>Journal of tropical pediatrics (1980), 2005-04, Vol.51 (2), p.98-101</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Apr 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-c22aecc0014c1c033f4248902879eaf4a28cd25fdf5b92d8bdfe9b6f4fb27eb93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16851951$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15677370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Kyung-Yil</creatorcontrib><creatorcontrib>Lee, Hyung-Shin</creatorcontrib><creatorcontrib>Hong, Ja-Hyun</creatorcontrib><creatorcontrib>Han, Ji-Whan</creatorcontrib><creatorcontrib>Lee, Joon-Sung</creatorcontrib><creatorcontrib>Whang, Kyung-Tai</creatorcontrib><title>High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory indices were performed three times: before IVIG treatment, 24 h after IVIG treatment, and 7 days after IVIG treatment. The white blood cell and neutrophil counts showed significant decreases 24 h and 7 days after IVIG administration. The erythrocyte sedimentation rate (ESR) increased significantly 24 h after IVIG, and the elevated level was sustained for 7 days. The levels of hemoglobin, albumin and inflammation-associated proteins, including C-reactive protein, decreased 24 h after IVIG treatment. Inflammation-associated proteins, except transferrin, decreased further to near normal levels after 7 days. On the other hand, IgM and IgA were not affected after 24 h, rather increased significantly after 7 days. High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Blood Sedimentation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunoglobulins, Intravenous - administration & dosage</subject><subject>Immunoglobulins, Intravenous - immunology</subject><subject>Immunoproteins - metabolism</subject><subject>Infant</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucocutaneous Lymph Node Syndrome - immunology</subject><subject>Mucocutaneous Lymph Node Syndrome - therapy</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1vEzEQhlcIREPLkSuykOC21Gt7v45pE5LQSEgFJMTF8nrHidNdO9jetPlH_EwcJWokTtZoHj3jmTdJ3mX4c4Zreh2c3cLmWvVrXJUvklHGijylRcFeJiOcMZIWlFYXyRvvNxhjUjH2OrnI8qIsaYlHyd-5Xq3T1npACxOc2IGxg0eLvh-MXXW2GTpt0MQ-GgeroRMBPAprQGMZ9C5WLVrCDjqPrIoC1Ym-F8G6fSxaLSM8fZKwDWjq9mHtrNwHQN-h1T2YIIK2Bt1HC4ozxnI49IJYwUF2Jx6FFw8aTbQH4eEqeaVE5-Ht6b1Mfn6Z_ridp8tvs8XteJlKRvKQSkIESInj6jKTmFLFCKvquHhZg1BMkEq2JFetypuatFXTKqibQjHVkBKaml4mn47erbN_BvCB99pL6DphIF6Gx8MVJOoi-OE_cGMHZ-LfOCGMsryqWITSIySd9d6B4lune-H2PMP8kB8_5seP-UX-_Uk6ND20Z_oUWAQ-ngDhpeiUE0Zqf-aKKs_qPDsP1j7A03NfuIe4AS1zPv_1m88ms6-kqG94Sf8BOyC4nQ</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Lee, Kyung-Yil</creator><creator>Lee, Hyung-Shin</creator><creator>Hong, Ja-Hyun</creator><creator>Han, Ji-Whan</creator><creator>Lee, Joon-Sung</creator><creator>Whang, Kyung-Tai</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease</title><author>Lee, Kyung-Yil ; Lee, Hyung-Shin ; Hong, Ja-Hyun ; Han, Ji-Whan ; Lee, Joon-Sung ; Whang, Kyung-Tai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-c22aecc0014c1c033f4248902879eaf4a28cd25fdf5b92d8bdfe9b6f4fb27eb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Blood Sedimentation</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunoglobulins, Intravenous - administration & dosage</topic><topic>Immunoglobulins, Intravenous - immunology</topic><topic>Immunoproteins - metabolism</topic><topic>Infant</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mucocutaneous Lymph Node Syndrome - immunology</topic><topic>Mucocutaneous Lymph Node Syndrome - therapy</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kyung-Yil</creatorcontrib><creatorcontrib>Lee, Hyung-Shin</creatorcontrib><creatorcontrib>Hong, Ja-Hyun</creatorcontrib><creatorcontrib>Han, Ji-Whan</creatorcontrib><creatorcontrib>Lee, Joon-Sung</creatorcontrib><creatorcontrib>Whang, Kyung-Tai</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kyung-Yil</au><au>Lee, Hyung-Shin</au><au>Hong, Ja-Hyun</au><au>Han, Ji-Whan</au><au>Lee, Joon-Sung</au><au>Whang, Kyung-Tai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>51</volume><issue>2</issue><spage>98</spage><epage>101</epage><pages>98-101</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory indices were performed three times: before IVIG treatment, 24 h after IVIG treatment, and 7 days after IVIG treatment. The white blood cell and neutrophil counts showed significant decreases 24 h and 7 days after IVIG administration. The erythrocyte sedimentation rate (ESR) increased significantly 24 h after IVIG, and the elevated level was sustained for 7 days. The levels of hemoglobin, albumin and inflammation-associated proteins, including C-reactive protein, decreased 24 h after IVIG treatment. Inflammation-associated proteins, except transferrin, decreased further to near normal levels after 7 days. On the other hand, IgM and IgA were not affected after 24 h, rather increased significantly after 7 days. High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15677370</pmid><doi>10.1093/tropej/fmh087</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-6338 |
| ispartof | Journal of tropical pediatrics (1980), 2005-04, Vol.51 (2), p.98-101 |
| issn | 0142-6338 1465-3664 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67762028 |
| source | MEDLINE; Oxford Journals |
| subjects | Acute Disease Biological and medical sciences Biomarkers - metabolism Blood Sedimentation Child Child, Preschool Down-Regulation Female General aspects Humans Immunoglobulins, Intravenous - administration & dosage Immunoglobulins, Intravenous - immunology Immunoproteins - metabolism Infant Inflammation - immunology Inflammation - metabolism Leukocyte Count Male Medical sciences Mucocutaneous Lymph Node Syndrome - immunology Mucocutaneous Lymph Node Syndrome - therapy Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T18%3A56%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High-dose%20Intravenous%20Immunoglobulin%20Downregulates%20the%20Activated%20Levels%20of%20Inflammatory%20Indices%20Except%20Erythrocyte%20Sedimentation%20Rate%20in%20Acute%20Stage%20of%20Kawasaki%20Disease&rft.jtitle=Journal%20of%20tropical%20pediatrics%20(1980)&rft.au=Lee,%20Kyung-Yil&rft.date=2005-04-01&rft.volume=51&rft.issue=2&rft.spage=98&rft.epage=101&rft.pages=98-101&rft.issn=0142-6338&rft.eissn=1465-3664&rft.coden=JTRPAO&rft_id=info:doi/10.1093/tropej/fmh087&rft_dat=%3Cproquest_cross%3E860339781%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=224345884&rft_id=info:pmid/15677370&rfr_iscdi=true |