The multi-herbal formula Guibi-tang enhances memory and increases cell proliferation in the rat hippocampus
Guibi-tang (GBT) is a multi-herbal medicinal formula that has been used to treat amnesia in the traditional Korean medicine system for hundreds of years. In this study, we investigated the effects of GBT on learning and memory function in Wistar rats by using the foot shock passive avoidance test. I...
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| Veröffentlicht in: | Neuroscience letters 2005-05, Vol.379 (3), p.205-208 |
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| creator | Oh, Myung Sook Huh, Youngbuhm Bae, Hyunsu Ahn, Duk Kyun Park, Seong Kyu |
| description | Guibi-tang (GBT) is a multi-herbal medicinal formula that has been used to treat amnesia in the traditional Korean medicine system for hundreds of years. In this study, we investigated the effects of GBT on learning and memory function in Wistar rats by using the foot shock passive avoidance test. In addition, cell proliferation was examined using 5-bromo-2-deoxyuridine (BrdU) uptake and immunostaining in the dentate gyrus of the rat hippocampus after oral administration of GBT. In the passive avoidance test, the retention time of the GBT-treated group was significantly longer (almost 2.5-fold) than that of the control group. The number of BrdU-immunoreactive cells in the dentate gyrus was significantly higher in the GBT-treated group (almost twofold) than in the control group. These results suggest that administration of GBT to rats not only improves learning and memory but also increases the proliferation of cells in the dentate gyrus of the hippocampus. |
| doi_str_mv | 10.1016/j.neulet.2004.12.077 |
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In this study, we investigated the effects of GBT on learning and memory function in Wistar rats by using the foot shock passive avoidance test. In addition, cell proliferation was examined using 5-bromo-2-deoxyuridine (BrdU) uptake and immunostaining in the dentate gyrus of the rat hippocampus after oral administration of GBT. In the passive avoidance test, the retention time of the GBT-treated group was significantly longer (almost 2.5-fold) than that of the control group. The number of BrdU-immunoreactive cells in the dentate gyrus was significantly higher in the GBT-treated group (almost twofold) than in the control group. These results suggest that administration of GBT to rats not only improves learning and memory but also increases the proliferation of cells in the dentate gyrus of the hippocampus.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2004.12.077</identifier><identifier>PMID: 15843064</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Avoidance Learning - drug effects ; Behavior, Animal - drug effects ; Biological and medical sciences ; Bromodeoxyuridine - metabolism ; Cell Count - methods ; Cell proliferation ; Cell Proliferation - drug effects ; Dentate gyrus ; Drugs, Chinese Herbal ; Fundamental and applied biological sciences. Psychology ; Guibi-tang ; Hippocampus - cytology ; Hippocampus - drug effects ; Immunohistochemistry - methods ; Learning and memory ; Male ; Memory - drug effects ; Passive avoidance test ; Plant Preparations - pharmacology ; Rats ; Rats, Wistar ; Reaction Time - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2005-05, Vol.379 (3), p.205-208</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-d96017c7c45938078971c82acce429f06cbb51dce1c6ceb2126bbf7be1238b6e3</citedby><cites>FETCH-LOGICAL-c487t-d96017c7c45938078971c82acce429f06cbb51dce1c6ceb2126bbf7be1238b6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2004.12.077$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16712470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15843064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Myung Sook</creatorcontrib><creatorcontrib>Huh, Youngbuhm</creatorcontrib><creatorcontrib>Bae, Hyunsu</creatorcontrib><creatorcontrib>Ahn, Duk Kyun</creatorcontrib><creatorcontrib>Park, Seong Kyu</creatorcontrib><title>The multi-herbal formula Guibi-tang enhances memory and increases cell proliferation in the rat hippocampus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Guibi-tang (GBT) is a multi-herbal medicinal formula that has been used to treat amnesia in the traditional Korean medicine system for hundreds of years. In this study, we investigated the effects of GBT on learning and memory function in Wistar rats by using the foot shock passive avoidance test. In addition, cell proliferation was examined using 5-bromo-2-deoxyuridine (BrdU) uptake and immunostaining in the dentate gyrus of the rat hippocampus after oral administration of GBT. In the passive avoidance test, the retention time of the GBT-treated group was significantly longer (almost 2.5-fold) than that of the control group. The number of BrdU-immunoreactive cells in the dentate gyrus was significantly higher in the GBT-treated group (almost twofold) than in the control group. These results suggest that administration of GBT to rats not only improves learning and memory but also increases the proliferation of cells in the dentate gyrus of the hippocampus.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Bromodeoxyuridine - metabolism</subject><subject>Cell Count - methods</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Dentate gyrus</subject><subject>Drugs, Chinese Herbal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guibi-tang</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Immunohistochemistry - methods</subject><subject>Learning and memory</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Passive avoidance test</subject><subject>Plant Preparations - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reaction Time - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxa0KRJeWb4CQL3BL8DiOnVyQUAUFqRKXcrbsyaTrJf-wk0r99vVqV-oNTtZ4fvP09B5j70GUIEB_PpQTbQOtpRRClSBLYcwF20FjZGFaI1-xnaiEKqpWiUv2NqWDEKKGWr1hl1A3qhJa7dif-z3xcRvWUOwpejfwfo55dvx2Cz4Uq5seOE17NyElPtI4xyfupo6HCSO5lD-RhoEvcR5CT9GtYZ7ykq9ZN098H5ZlRjcuW7pmr3s3JHp3fq_Y7-_f7m9-FHe_bn_efL0rUDVmLbpWCzBoUNVt1QjTtAawkQ6RlGx7odH7GjokQI3kJUjtfW88gawar6m6Yp9OutnU343SaseQji7dRPOWrDZG5wjVf0EwStY1VBlUJxDjnFKk3i4xjC4-WRD22IY92FMb9tiGBWlzG_nsw1l_8yN1L0fn-DPw8Qy4hG7oY445pBdOG5DKiMx9OXGUY3sMFG3CQLmSLkTC1XZz-LeTZ3iOq7E</recordid><startdate>20050513</startdate><enddate>20050513</enddate><creator>Oh, Myung Sook</creator><creator>Huh, Youngbuhm</creator><creator>Bae, Hyunsu</creator><creator>Ahn, Duk Kyun</creator><creator>Park, Seong Kyu</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050513</creationdate><title>The multi-herbal formula Guibi-tang enhances memory and increases cell proliferation in the rat hippocampus</title><author>Oh, Myung Sook ; Huh, Youngbuhm ; Bae, Hyunsu ; Ahn, Duk Kyun ; Park, Seong Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-d96017c7c45938078971c82acce429f06cbb51dce1c6ceb2126bbf7be1238b6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Bromodeoxyuridine - metabolism</topic><topic>Cell Count - methods</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Dentate gyrus</topic><topic>Drugs, Chinese Herbal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guibi-tang</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Immunohistochemistry - methods</topic><topic>Learning and memory</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Passive avoidance test</topic><topic>Plant Preparations - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Myung Sook</creatorcontrib><creatorcontrib>Huh, Youngbuhm</creatorcontrib><creatorcontrib>Bae, Hyunsu</creatorcontrib><creatorcontrib>Ahn, Duk Kyun</creatorcontrib><creatorcontrib>Park, Seong Kyu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Myung Sook</au><au>Huh, Youngbuhm</au><au>Bae, Hyunsu</au><au>Ahn, Duk Kyun</au><au>Park, Seong Kyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The multi-herbal formula Guibi-tang enhances memory and increases cell proliferation in the rat hippocampus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2005-05-13</date><risdate>2005</risdate><volume>379</volume><issue>3</issue><spage>205</spage><epage>208</epage><pages>205-208</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Guibi-tang (GBT) is a multi-herbal medicinal formula that has been used to treat amnesia in the traditional Korean medicine system for hundreds of years. In this study, we investigated the effects of GBT on learning and memory function in Wistar rats by using the foot shock passive avoidance test. In addition, cell proliferation was examined using 5-bromo-2-deoxyuridine (BrdU) uptake and immunostaining in the dentate gyrus of the rat hippocampus after oral administration of GBT. In the passive avoidance test, the retention time of the GBT-treated group was significantly longer (almost 2.5-fold) than that of the control group. The number of BrdU-immunoreactive cells in the dentate gyrus was significantly higher in the GBT-treated group (almost twofold) than in the control group. These results suggest that administration of GBT to rats not only improves learning and memory but also increases the proliferation of cells in the dentate gyrus of the hippocampus.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15843064</pmid><doi>10.1016/j.neulet.2004.12.077</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Biological and medical sciences Bromodeoxyuridine - metabolism Cell Count - methods Cell proliferation Cell Proliferation - drug effects Dentate gyrus Drugs, Chinese Herbal Fundamental and applied biological sciences. Psychology Guibi-tang Hippocampus - cytology Hippocampus - drug effects Immunohistochemistry - methods Learning and memory Male Memory - drug effects Passive avoidance test Plant Preparations - pharmacology Rats Rats, Wistar Reaction Time - drug effects Vertebrates: nervous system and sense organs |
| title | The multi-herbal formula Guibi-tang enhances memory and increases cell proliferation in the rat hippocampus |
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