Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme

To determine the importance of fibroblast growth factor receptors ( fgfrs) 1 and 2 in the metanephric mesenchyme, we generated conditional knockout mice ( fgfr Mes−/− ). Fgfr1 Mes−/− and fgfr2 Mes−/− mice develop normal-appearing kidneys. Deletion of both receptors ( fgfr1/2 Mes−/− ) results in rena...

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Veröffentlicht in:	Developmental biology 2006-03, Vol.291 (2), p.325-339
Hauptverfasser:	Poladia, Deepali Pitre, Kish, Kayle, Kutay, Benjamin, Hains, David, Kegg, Heather, Zhao, Haotian, Bates, Carlton M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Proliferation Conditional knockout Fibroblast growth factor receptor Gene Expression Profiling In Situ Nick-End Labeling Kidney - abnormalities Kidney - embryology Kidney development Mesoderm - physiology Metanephric mesenchyme Mice Mice, Knockout PAX2 Transcription Factor - genetics PAX2 Transcription Factor - physiology Pax3 promoter Receptor, Fibroblast Growth Factor, Type 1 - physiology Receptor, Fibroblast Growth Factor, Type 2 - physiology
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