Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy

In dystrophinopathies, disease severity is generally related to the extent of muscle fibrosis. To determine whether a decrease in matrix degradation contributes to the severe fibrosis seen in Duchenne muscular dystrophy (DMD), we quantified RNA transcript numbers for the fibrolytic matrix metallopro...

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Veröffentlicht in:	Acta neuropathologica 2005-04, Vol.109 (3), p.285-293
Hauptverfasser:	von Moers, Arpad, Zwirner, Angelika, Reinhold, Anke, Brückmann, Olaf, van Landeghem, Frank, Stoltenburg-Didinger, Gisela, Schuppan, Detlef, Herbst, Herrman, Schuelke, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Child Child, Preschool DNA Mutational Analysis Electrophoresis - methods Humans Immunohistochemistry - methods Male Muscles - drug effects Muscles - enzymology Muscular Dystrophy, Duchenne - enzymology Muscular Dystrophy, Duchenne - genetics Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Antisense - pharmacology RNA, Messenger - metabolism Statistics, Nonparametric Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - metabolism Up-Regulation - physiology Vimentin - metabolism
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