Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling

During infection of macrophages, prolonged signaling by Mycobacterium tuberculosis (Mtb) or its 19-kDa lipoprotein (LpqH; Rv3763) inhibits IFN-gamma-induced expression of several immune function genes, including class II transactivator (CIITA), which regulates class II MHC. Mtb does not inhibit earl...

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Veröffentlicht in:	Journal of Immunology 2006-04, Vol.176 (7), p.4323-4330
Hauptverfasser:	Pennini, Meghan E, Pai, Rish K, Schultz, David C, Boom, W Henry, Harding, Clifford V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Bacterial Proteins - metabolism Bacterial Proteins - pharmacology Cell Line Chromatin Assembly and Disassembly - drug effects Enzyme Activation - drug effects Genes, Reporter - genetics Histones - chemistry Histones - metabolism Interferon-gamma - pharmacology Lipoproteins - metabolism Lipoproteins - pharmacology MAP Kinase Signaling System - drug effects Mice Mitogen-Activated Protein Kinases - metabolism Molecular Weight Mycobacterium tuberculosis Mycobacterium tuberculosis - metabolism Nitric Oxide Synthase Type II - genetics Nuclear Proteins - genetics Promoter Regions, Genetic - genetics Time Factors Toll-Like Receptor 2 - metabolism Trans-Activators - genetics Transfection
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