Synthesis and Antiviral Evaluation of Alkoxyalkyl Derivatives of 9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine against Cytomegalovirus and Orthopoxviruses

9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine [(S)-HPMPA] was one of the first acyclic nucleoside phosphonates described and has been reported to have good antiviral activity against most double-stranded DNA viruses, including the herpes group viruses and the orthopoxviruses. However, (S)-HPMPA...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-03, Vol.49 (6), p.2010-2015
Hauptverfasser:	Beadle, James R, Wan, William B, Ciesla, Stephanie L, Keith, Kathy A, Hartline, Caroll, Kern, Earl R, Hostetler, Karl Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemical synthesis Adenine - chemistry Adenine - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Line Cytomegalovirus - drug effects Esters - chemical synthesis Esters - chemistry Esters - pharmacology Human cytomegalovirus Humans Medical sciences Murine cytomegalovirus Organophosphonates - chemical synthesis Organophosphonates - chemistry Organophosphonates - pharmacology Orthopoxvirus - drug effects Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship
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