Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas
Biologic and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas (IPMTs) were studied in reference to immunohistochemical mucin (MUC1, MUC2, and MUC5AC) expression. Histologic grade, immunohistochemical ki-67 and p53 expression, and findings in imaging tests of 21 IPMTs...
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| Veröffentlicht in: | Pancreas 2005-05, Vol.30 (4), p.e96-e102 |
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| container_title | Pancreas |
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| creator | Ito, Hideto Endo, Takao Oka, Toshikuni Matumoto, Takeshi Abe, Tamaki Toyota, Minoru Imai, Kohzoh Satoh, Masaaki Maguchi, Hiroyuki Shinohara, Toshiya |
| description | Biologic and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas (IPMTs) were studied in reference to immunohistochemical mucin (MUC1, MUC2, and MUC5AC) expression.
Histologic grade, immunohistochemical ki-67 and p53 expression, and findings in imaging tests of 21 IPMTs (9 carcinomas, 6 borderline tumors, and 6 adenomas) were examined according to the mucin expression profile.
IPMTs were divided into groups: M1 group (MUC1+, n = 4), M2 group (MUC2 + MUC1-, n = 12), and M5 group (MUC5AC + MUC1-MUC2-, n = 5). The M2 group was subdivided into M2s (strongly positive) and M2w (weakly positive) groups. The rates of carcinoma in the M1, M2s, M2w, and M5 groups were 100%, 40%, 0%, and 0%, respectively. The Ki-67 labeling indexes were significantly higher in the M1 and M2s groups. p53 staining was positive in 50% and 40% of the IPMTs in the M1 and M2s groups, respectively, but in none of the IPMT in the M2w and M5 groups. Morphologic changes in imaging tests during the observation periods were most remarkable in the M1 group.
Our results suggest that MUC1 is related to malignant character but MUC5AC alone is related to benign character in IPMTs and that malignant potential of IPMTs expressing MUC2 depends on the degree of MUC2 expression. |
| doi_str_mv | 10.1097/01.mpa.0000163358.90111.ab |
| format | Article |
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Histologic grade, immunohistochemical ki-67 and p53 expression, and findings in imaging tests of 21 IPMTs (9 carcinomas, 6 borderline tumors, and 6 adenomas) were examined according to the mucin expression profile.
IPMTs were divided into groups: M1 group (MUC1+, n = 4), M2 group (MUC2 + MUC1-, n = 12), and M5 group (MUC5AC + MUC1-MUC2-, n = 5). The M2 group was subdivided into M2s (strongly positive) and M2w (weakly positive) groups. The rates of carcinoma in the M1, M2s, M2w, and M5 groups were 100%, 40%, 0%, and 0%, respectively. The Ki-67 labeling indexes were significantly higher in the M1 and M2s groups. p53 staining was positive in 50% and 40% of the IPMTs in the M1 and M2s groups, respectively, but in none of the IPMT in the M2w and M5 groups. Morphologic changes in imaging tests during the observation periods were most remarkable in the M1 group.
Our results suggest that MUC1 is related to malignant character but MUC5AC alone is related to benign character in IPMTs and that malignant potential of IPMTs expressing MUC2 depends on the degree of MUC2 expression.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/01.mpa.0000163358.90111.ab</identifier><identifier>PMID: 15841035</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma, Mucinous - metabolism ; Adenocarcinoma, Mucinous - mortality ; Adenocarcinoma, Mucinous - pathology ; Adult ; Aged ; Biomarkers, Tumor - metabolism ; Carcinoma, Papillary - metabolism ; Carcinoma, Papillary - mortality ; Carcinoma, Papillary - pathology ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen - metabolism ; Male ; Middle Aged ; Mucin 5AC ; Mucin-1 - metabolism ; Mucin-2 ; Mucins - metabolism ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Survival Rate ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Pancreas, 2005-05, Vol.30 (4), p.e96-e102</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-4dd314187ce5e9acb51233e78c8f4840ff1c3000e1c256f83ecbdfa4c04f4c123</citedby><cites>FETCH-LOGICAL-c383t-4dd314187ce5e9acb51233e78c8f4840ff1c3000e1c256f83ecbdfa4c04f4c123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15841035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Hideto</creatorcontrib><creatorcontrib>Endo, Takao</creatorcontrib><creatorcontrib>Oka, Toshikuni</creatorcontrib><creatorcontrib>Matumoto, Takeshi</creatorcontrib><creatorcontrib>Abe, Tamaki</creatorcontrib><creatorcontrib>Toyota, Minoru</creatorcontrib><creatorcontrib>Imai, Kohzoh</creatorcontrib><creatorcontrib>Satoh, Masaaki</creatorcontrib><creatorcontrib>Maguchi, Hiroyuki</creatorcontrib><creatorcontrib>Shinohara, Toshiya</creatorcontrib><title>Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>Biologic and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas (IPMTs) were studied in reference to immunohistochemical mucin (MUC1, MUC2, and MUC5AC) expression.
Histologic grade, immunohistochemical ki-67 and p53 expression, and findings in imaging tests of 21 IPMTs (9 carcinomas, 6 borderline tumors, and 6 adenomas) were examined according to the mucin expression profile.
IPMTs were divided into groups: M1 group (MUC1+, n = 4), M2 group (MUC2 + MUC1-, n = 12), and M5 group (MUC5AC + MUC1-MUC2-, n = 5). The M2 group was subdivided into M2s (strongly positive) and M2w (weakly positive) groups. The rates of carcinoma in the M1, M2s, M2w, and M5 groups were 100%, 40%, 0%, and 0%, respectively. The Ki-67 labeling indexes were significantly higher in the M1 and M2s groups. p53 staining was positive in 50% and 40% of the IPMTs in the M1 and M2s groups, respectively, but in none of the IPMT in the M2w and M5 groups. Morphologic changes in imaging tests during the observation periods were most remarkable in the M1 group.
Our results suggest that MUC1 is related to malignant character but MUC5AC alone is related to benign character in IPMTs and that malignant potential of IPMTs expressing MUC2 depends on the degree of MUC2 expression.</description><subject>Adenocarcinoma, Mucinous - metabolism</subject><subject>Adenocarcinoma, Mucinous - mortality</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Carcinoma, Papillary - mortality</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucin 5AC</subject><subject>Mucin-1 - metabolism</subject><subject>Mucin-2</subject><subject>Mucins - metabolism</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Survival Rate</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAQxy1ERbeFV0AWB24JnnW8drihqoVKRb3A2XImY2qUxMF2JHgCXrvudqXOZTSa33z-GfsAogXR608C2nl1ragGBymVaXsBAK0bXrEdKHloOrM3r9lOGKMaCVqfs4ucf1dcS9W_YeegTAdCqh37_33DsHD6uybKOcSFryn6MBEPmSeaXKGRl8iHEKf4K6CbuFtGjlNYjgE-uOSwUAq5BMw8eh6Wkty4Yanp1a1hmlz618xPc-KWednmmI5geaAKLJjI5bfszLsp07uTv2Q_b65_XH1r7u6_3l59uWtQGlmabhwldGA0kqLe4aBgLyVpg8Z3phPeA8r6FwLcq4M3knAYvetQdL7Dyl6yj89965l_NsrFziEj1R0XqtvZg9aql0JX8PMziCnmnMjbNYW5XmJB2CcZrABbZbAvMtijDNYNtfj9aco2zDS-lJ7-Lh8BZk6JNA</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Ito, Hideto</creator><creator>Endo, Takao</creator><creator>Oka, Toshikuni</creator><creator>Matumoto, Takeshi</creator><creator>Abe, Tamaki</creator><creator>Toyota, Minoru</creator><creator>Imai, Kohzoh</creator><creator>Satoh, Masaaki</creator><creator>Maguchi, Hiroyuki</creator><creator>Shinohara, Toshiya</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas</title><author>Ito, Hideto ; Endo, Takao ; Oka, Toshikuni ; Matumoto, Takeshi ; Abe, Tamaki ; Toyota, Minoru ; Imai, Kohzoh ; Satoh, Masaaki ; Maguchi, Hiroyuki ; Shinohara, Toshiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-4dd314187ce5e9acb51233e78c8f4840ff1c3000e1c256f83ecbdfa4c04f4c123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenocarcinoma, Mucinous - metabolism</topic><topic>Adenocarcinoma, Mucinous - mortality</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Carcinoma, Papillary - mortality</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucin 5AC</topic><topic>Mucin-1 - metabolism</topic><topic>Mucin-2</topic><topic>Mucins - metabolism</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Survival Rate</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Hideto</creatorcontrib><creatorcontrib>Endo, Takao</creatorcontrib><creatorcontrib>Oka, Toshikuni</creatorcontrib><creatorcontrib>Matumoto, Takeshi</creatorcontrib><creatorcontrib>Abe, Tamaki</creatorcontrib><creatorcontrib>Toyota, Minoru</creatorcontrib><creatorcontrib>Imai, Kohzoh</creatorcontrib><creatorcontrib>Satoh, Masaaki</creatorcontrib><creatorcontrib>Maguchi, Hiroyuki</creatorcontrib><creatorcontrib>Shinohara, Toshiya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Hideto</au><au>Endo, Takao</au><au>Oka, Toshikuni</au><au>Matumoto, Takeshi</au><au>Abe, Tamaki</au><au>Toyota, Minoru</au><au>Imai, Kohzoh</au><au>Satoh, Masaaki</au><au>Maguchi, Hiroyuki</au><au>Shinohara, Toshiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>30</volume><issue>4</issue><spage>e96</spage><epage>e102</epage><pages>e96-e102</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><abstract>Biologic and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas (IPMTs) were studied in reference to immunohistochemical mucin (MUC1, MUC2, and MUC5AC) expression.
Histologic grade, immunohistochemical ki-67 and p53 expression, and findings in imaging tests of 21 IPMTs (9 carcinomas, 6 borderline tumors, and 6 adenomas) were examined according to the mucin expression profile.
IPMTs were divided into groups: M1 group (MUC1+, n = 4), M2 group (MUC2 + MUC1-, n = 12), and M5 group (MUC5AC + MUC1-MUC2-, n = 5). The M2 group was subdivided into M2s (strongly positive) and M2w (weakly positive) groups. The rates of carcinoma in the M1, M2s, M2w, and M5 groups were 100%, 40%, 0%, and 0%, respectively. The Ki-67 labeling indexes were significantly higher in the M1 and M2s groups. p53 staining was positive in 50% and 40% of the IPMTs in the M1 and M2s groups, respectively, but in none of the IPMT in the M2w and M5 groups. Morphologic changes in imaging tests during the observation periods were most remarkable in the M1 group.
Our results suggest that MUC1 is related to malignant character but MUC5AC alone is related to benign character in IPMTs and that malignant potential of IPMTs expressing MUC2 depends on the degree of MUC2 expression.</abstract><cop>United States</cop><pmid>15841035</pmid><doi>10.1097/01.mpa.0000163358.90111.ab</doi></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - mortality Adenocarcinoma, Mucinous - pathology Adult Aged Biomarkers, Tumor - metabolism Carcinoma, Papillary - metabolism Carcinoma, Papillary - mortality Carcinoma, Papillary - pathology Female Humans Immunohistochemistry Ki-67 Antigen - metabolism Male Middle Aged Mucin 5AC Mucin-1 - metabolism Mucin-2 Mucins - metabolism Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Survival Rate Tumor Suppressor Protein p53 - metabolism |
| title | Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas |
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