Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins
This study compared protection of pigs against lethal Pseudorabies virus (PrV) infection induced by a single injection of various quantities of Sindbis virus-derived plasmids encoding PrV glycoproteins gB, gC and gD. Pigs were injected with 340, 68 or 13 μg of each plasmid. Few immune differences we...
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| Veröffentlicht in: | Vaccine 2005-05, Vol.23 (26), p.3483-3491 |
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| creator | Dory, Daniel Torché, Anne-Marie Béven, Véronique Blanchard, Philippe Loizel, Christophe Cariolet, Roland Jestin, André |
| description | This study compared protection of pigs against lethal Pseudorabies virus (PrV) infection induced by a single injection of various quantities of Sindbis virus-derived plasmids encoding PrV glycoproteins gB, gC and gD. Pigs were injected with 340, 68 or 13
μg of each plasmid. Few immune differences were observed after DNA injection and more importantly the pigs of the three groups were equally protected against virulent PrV infection. Single-shot injection of 13
μg of each PrV glycoprotein encoding Sindbis virus-derived plasmid is able to effectively protect pigs from PrV infection. |
| doi_str_mv | 10.1016/j.vaccine.2004.10.050 |
| format | Article |
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μg of each plasmid. Few immune differences were observed after DNA injection and more importantly the pigs of the three groups were equally protected against virulent PrV infection. Single-shot injection of 13
μg of each PrV glycoprotein encoding Sindbis virus-derived plasmid is able to effectively protect pigs from PrV infection.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2004.10.050</identifier><identifier>PMID: 15837372</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Applied microbiology ; Aujeszky's disease ; Biological and medical sciences ; Body temperature ; Cloning ; Cytokines ; Cytotoxicity ; Deoxyribonucleic acid ; DNA ; DNA vaccine ; Fundamental and applied biological sciences. Psychology ; Genetic Vectors - genetics ; Glycoproteins ; Herpesvirus 1, Suid - drug effects ; Herpesvirus 1, Suid - genetics ; Herpesvirus 1, Suid - immunology ; Infections ; Injection ; Microbiology ; Miscellaneous ; Plasmids ; Pseudorabies - immunology ; Pseudorabies - prevention & control ; Pseudorabies Vaccines - administration & dosage ; Pseudorabies Vaccines - immunology ; Replicon transcription amplification ; Swine ; Swine Diseases - immunology ; Swine Diseases - prevention & control ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, DNA - administration & dosage ; Vaccines, DNA - immunology ; Viral Envelope Proteins - genetics ; Viral Envelope Proteins - immunology ; Viral infections ; Virology</subject><ispartof>Vaccine, 2005-05, Vol.23 (26), p.3483-3491</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 16, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-a383e15006d83bb2fc00bc8787d1af4760af431bf941c6a24070a83f36c5226c3</citedby><cites>FETCH-LOGICAL-c452t-a383e15006d83bb2fc00bc8787d1af4760af431bf941c6a24070a83f36c5226c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1559074063?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17589492$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15837372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dory, Daniel</creatorcontrib><creatorcontrib>Torché, Anne-Marie</creatorcontrib><creatorcontrib>Béven, Véronique</creatorcontrib><creatorcontrib>Blanchard, Philippe</creatorcontrib><creatorcontrib>Loizel, Christophe</creatorcontrib><creatorcontrib>Cariolet, Roland</creatorcontrib><creatorcontrib>Jestin, André</creatorcontrib><title>Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>This study compared protection of pigs against lethal Pseudorabies virus (PrV) infection induced by a single injection of various quantities of Sindbis virus-derived plasmids encoding PrV glycoproteins gB, gC and gD. Pigs were injected with 340, 68 or 13
μg of each plasmid. Few immune differences were observed after DNA injection and more importantly the pigs of the three groups were equally protected against virulent PrV infection. Single-shot injection of 13
μg of each PrV glycoprotein encoding Sindbis virus-derived plasmid is able to effectively protect pigs from PrV infection.</description><subject>Animals</subject><subject>Applied microbiology</subject><subject>Aujeszky's disease</subject><subject>Biological and medical sciences</subject><subject>Body temperature</subject><subject>Cloning</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA vaccine</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genetic Vectors - genetics</topic><topic>Glycoproteins</topic><topic>Herpesvirus 1, Suid - drug effects</topic><topic>Herpesvirus 1, Suid - genetics</topic><topic>Herpesvirus 1, Suid - immunology</topic><topic>Infections</topic><topic>Injection</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Plasmids</topic><topic>Pseudorabies - immunology</topic><topic>Pseudorabies - prevention & control</topic><topic>Pseudorabies Vaccines - administration & dosage</topic><topic>Pseudorabies Vaccines - immunology</topic><topic>Replicon transcription amplification</topic><topic>Swine</topic><topic>Swine Diseases - immunology</topic><topic>Swine Diseases - prevention & control</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, DNA - administration & dosage</topic><topic>Vaccines, DNA - immunology</topic><topic>Viral Envelope Proteins - genetics</topic><topic>Viral Envelope Proteins - immunology</topic><topic>Viral infections</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dory, Daniel</creatorcontrib><creatorcontrib>Torché, Anne-Marie</creatorcontrib><creatorcontrib>Béven, Véronique</creatorcontrib><creatorcontrib>Blanchard, Philippe</creatorcontrib><creatorcontrib>Loizel, Christophe</creatorcontrib><creatorcontrib>Cariolet, Roland</creatorcontrib><creatorcontrib>Jestin, André</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dory, Daniel</au><au>Torché, Anne-Marie</au><au>Béven, Véronique</au><au>Blanchard, Philippe</au><au>Loizel, Christophe</au><au>Cariolet, Roland</au><au>Jestin, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2005-05-16</date><risdate>2005</risdate><volume>23</volume><issue>26</issue><spage>3483</spage><epage>3491</epage><pages>3483-3491</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>This study compared protection of pigs against lethal Pseudorabies virus (PrV) infection induced by a single injection of various quantities of Sindbis virus-derived plasmids encoding PrV glycoproteins gB, gC and gD. Pigs were injected with 340, 68 or 13
μg of each plasmid. Few immune differences were observed after DNA injection and more importantly the pigs of the three groups were equally protected against virulent PrV infection. Single-shot injection of 13
μg of each PrV glycoprotein encoding Sindbis virus-derived plasmid is able to effectively protect pigs from PrV infection.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15837372</pmid><doi>10.1016/j.vaccine.2004.10.050</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2005-05, Vol.23 (26), p.3483-3491 |
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| subjects | Animals Applied microbiology Aujeszky's disease Biological and medical sciences Body temperature Cloning Cytokines Cytotoxicity Deoxyribonucleic acid DNA DNA vaccine Fundamental and applied biological sciences. Psychology Genetic Vectors - genetics Glycoproteins Herpesvirus 1, Suid - drug effects Herpesvirus 1, Suid - genetics Herpesvirus 1, Suid - immunology Infections Injection Microbiology Miscellaneous Plasmids Pseudorabies - immunology Pseudorabies - prevention & control Pseudorabies Vaccines - administration & dosage Pseudorabies Vaccines - immunology Replicon transcription amplification Swine Swine Diseases - immunology Swine Diseases - prevention & control Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral infections Virology |
| title | Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins |
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