Induction of hypoxia inducible factor‐1 attenuates metabolic insults induced by 3‐nitropropionic acid in rat C6 glioma cells

Compromised mitochondrial function in neurons and glia has been observed in several neurodegenerative disorders, including Huntington's disease and Alzheimer's disease. Chemical/hypoxic preconditioning may afford protection against subsequently more severe oxidative damages. In this study,...

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Veröffentlicht in:	Journal of neurochemistry 2005-05, Vol.93 (3), p.513-525
Hauptverfasser:	Yang, Ya‐Ting, Ju, Tzyh‐Chwen, Yang, Ding‐I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antisense oligodeoxynucleotide Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cell Line, Tumor Cell Survival - drug effects Cell Survival - physiology Cobalt - pharmacology cobalt chloride Deferoxamine - pharmacology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases desferrioxamine DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - physiology Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Medical sciences mimosine Mimosine - pharmacology Neurology Nitro Compounds Nuclear Proteins - biosynthesis Nuclear Proteins - physiology oligodeoxynucleotide decoy preconditioning Propionates - pharmacology Rats Signal Transduction - drug effects Signal Transduction - physiology Transcription Factors - biosynthesis Transcription Factors - physiology Tumors of the nervous system. Phacomatoses
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