Therapeutic Immunization with Dendritic Cells Loaded with Heat-Inactivated Autologous HIV-1 in Patients with Chronic HIV-1 Infection
Therapeutic immunization with autologous monocyte-derived dendritic cells (DCs) loaded with heat-inactivated autologous human immunodeficiency virus type 1 (HIV-1) in 12 patients with chronic HIV-1 infection who were receiving highly active antiretroviral therapy (HAART) was feasible, safe, and well...
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| Veröffentlicht in: | The Journal of infectious diseases 2005-05, Vol.191 (10), p.1680-1685 |
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| creator | García, Felipe Lejeune, Merylene Climent, Nuria Gil, Cristina Alcamí, José Morente, Vanessa Alós, Llucia Ruiz, Alba Setoain, Javier Fumero, Emilio Castro, Pedro López, Anna Cruceta, Anna Piera, Carlos Florence, Eric Pereira, Arturo Libois, Agnes González, Nuria Guilá, Meritxell Caballero, Miguel Lomeña, Francisco Joseph, Joan Miró, José M Pumarola, Tomás Plana, Montserrat Gatell, José M Gallart, Teresa |
| description | Therapeutic immunization with autologous monocyte-derived dendritic cells (DCs) loaded with heat-inactivated autologous human immunodeficiency virus type 1 (HIV-1) in 12 patients with chronic HIV-1 infection who were receiving highly active antiretroviral therapy (HAART) was feasible, safe, and well tolerated. Virus was obtained during an initial interruption of HAART (hereafter, “stop 1”) so that DCs could be pulsed. After immunization and a second interruption of HAART (hereafter, “stop 2”), set-point plasma viral load (PVL; 24 weeks after stop 2) decreased ⩾0.5 log10 copies/mL relative to baseline PVL in 4 of 12 patients. We observed a significant lengthening in mean doubling time of PVL rebound and significant decreases in the area under the curve and the mean peak of PVL rebound after stop 2, compared with those after stop 1. This response was associated with changes in HIV—1 specific CD4+ lymphoproliferative and CD8+ T cell responses. These changes were not observed in a group of nonimmunized control patients. |
| doi_str_mv | 10.1086/429340 |
| format | Article |
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Virus was obtained during an initial interruption of HAART (hereafter, “stop 1”) so that DCs could be pulsed. After immunization and a second interruption of HAART (hereafter, “stop 2”), set-point plasma viral load (PVL; 24 weeks after stop 2) decreased ⩾0.5 log10 copies/mL relative to baseline PVL in 4 of 12 patients. We observed a significant lengthening in mean doubling time of PVL rebound and significant decreases in the area under the curve and the mean peak of PVL rebound after stop 2, compared with those after stop 1. This response was associated with changes in HIV—1 specific CD4+ lymphoproliferative and CD8+ T cell responses. These changes were not observed in a group of nonimmunized control patients.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/429340</identifier><identifier>PMID: 15838795</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS Vaccines - therapeutic use ; Antiretroviral Therapy, Highly Active ; Applied microbiology ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - physiology ; CD8-Positive T-Lymphocytes - physiology ; Dendritic Cells - immunology ; Fundamental and applied biological sciences. Psychology ; HIV Infections - drug therapy ; HIV Infections - therapy ; HIV-1 - immunology ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Inactivated - therapeutic use ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load</subject><ispartof>The Journal of infectious diseases, 2005-05, Vol.191 (10), p.1680-1685</ispartof><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright University of Chicago Press May 15, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-ea2471a440099c15cdbb1c796576d60a0abde41f63048aca9f5c9ff6553762553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16826004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15838795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García, Felipe</creatorcontrib><creatorcontrib>Lejeune, Merylene</creatorcontrib><creatorcontrib>Climent, Nuria</creatorcontrib><creatorcontrib>Gil, Cristina</creatorcontrib><creatorcontrib>Alcamí, José</creatorcontrib><creatorcontrib>Morente, Vanessa</creatorcontrib><creatorcontrib>Alós, Llucia</creatorcontrib><creatorcontrib>Ruiz, Alba</creatorcontrib><creatorcontrib>Setoain, Javier</creatorcontrib><creatorcontrib>Fumero, Emilio</creatorcontrib><creatorcontrib>Castro, Pedro</creatorcontrib><creatorcontrib>López, Anna</creatorcontrib><creatorcontrib>Cruceta, Anna</creatorcontrib><creatorcontrib>Piera, Carlos</creatorcontrib><creatorcontrib>Florence, Eric</creatorcontrib><creatorcontrib>Pereira, Arturo</creatorcontrib><creatorcontrib>Libois, Agnes</creatorcontrib><creatorcontrib>González, Nuria</creatorcontrib><creatorcontrib>Guilá, Meritxell</creatorcontrib><creatorcontrib>Caballero, Miguel</creatorcontrib><creatorcontrib>Lomeña, Francisco</creatorcontrib><creatorcontrib>Joseph, Joan</creatorcontrib><creatorcontrib>Miró, José M</creatorcontrib><creatorcontrib>Pumarola, Tomás</creatorcontrib><creatorcontrib>Plana, Montserrat</creatorcontrib><creatorcontrib>Gatell, José M</creatorcontrib><creatorcontrib>Gallart, Teresa</creatorcontrib><title>Therapeutic Immunization with Dendritic Cells Loaded with Heat-Inactivated Autologous HIV-1 in Patients with Chronic HIV-1 Infection</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>Therapeutic immunization with autologous monocyte-derived dendritic cells (DCs) loaded with heat-inactivated autologous human immunodeficiency virus type 1 (HIV-1) in 12 patients with chronic HIV-1 infection who were receiving highly active antiretroviral therapy (HAART) was feasible, safe, and well tolerated. Virus was obtained during an initial interruption of HAART (hereafter, “stop 1”) so that DCs could be pulsed. After immunization and a second interruption of HAART (hereafter, “stop 2”), set-point plasma viral load (PVL; 24 weeks after stop 2) decreased ⩾0.5 log10 copies/mL relative to baseline PVL in 4 of 12 patients. We observed a significant lengthening in mean doubling time of PVL rebound and significant decreases in the area under the curve and the mean peak of PVL rebound after stop 2, compared with those after stop 1. This response was associated with changes in HIV—1 specific CD4+ lymphoproliferative and CD8+ T cell responses. These changes were not observed in a group of nonimmunized control patients.</description><subject>AIDS Vaccines - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - physiology</subject><subject>CD8-Positive T-Lymphocytes - physiology</subject><subject>Dendritic Cells - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - therapy</subject><subject>HIV-1 - immunology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Inactivated - therapeutic use</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Virus was obtained during an initial interruption of HAART (hereafter, “stop 1”) so that DCs could be pulsed. After immunization and a second interruption of HAART (hereafter, “stop 2”), set-point plasma viral load (PVL; 24 weeks after stop 2) decreased ⩾0.5 log10 copies/mL relative to baseline PVL in 4 of 12 patients. We observed a significant lengthening in mean doubling time of PVL rebound and significant decreases in the area under the curve and the mean peak of PVL rebound after stop 2, compared with those after stop 1. This response was associated with changes in HIV—1 specific CD4+ lymphoproliferative and CD8+ T cell responses. These changes were not observed in a group of nonimmunized control patients.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15838795</pmid><doi>10.1086/429340</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2005-05, Vol.191 (10), p.1680-1685 |
| issn | 0022-1899 1537-6613 |
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| subjects | AIDS Vaccines - therapeutic use Antiretroviral Therapy, Highly Active Applied microbiology Biological and medical sciences CD4-Positive T-Lymphocytes - physiology CD8-Positive T-Lymphocytes - physiology Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - therapy HIV-1 - immunology Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Medical sciences Microbiology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Inactivated - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load |
| title | Therapeutic Immunization with Dendritic Cells Loaded with Heat-Inactivated Autologous HIV-1 in Patients with Chronic HIV-1 Infection |
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