The pur3 gene from the pur cluster encodes a monophosphatase essential for puromycin biosynthesis in Streptomyces

The pur3 gene of the puromycin ( pur) cluster from Streptomyces alboniger is essential for the biosynthesis of this antibiotic. Cell extracts from Streptomyces lividans containing pur3 had monophosphatase activity versus a variety of mononucleotides including 3′-amino-3′-dAMP (3′-N-3′-dAMP), ( N 6,...

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Veröffentlicht in:	FEBS letters 2006-03, Vol.580 (7), p.1807-1811
Hauptverfasser:	Sánchez, María Blanca, Barrado, Patricia, Jiménez, Antonio, Fernández Lobato, María
Format:	Artikel
Sprache:	eng
Schlagworte:	3′-amino-3′-deoxyadenosine-5′-monophospate 3′-N-3′-dAMP Cloning, Molecular Escherichia coli Escherichia coli - genetics Kinetics Monophosphatase Multigene Family Nucleotides - metabolism Pac PAN PAN- 5′-P Phosphoric Monoester Hydrolases - genetics pur cluster pur3 gene Puromycin - biosynthesis puromycin aminonucleoside 5′-monophosphate, (N 6,N 6)-dimethyl-3′-amino-3′-dAMP puromycin aminonucleoside, (N 6,N 6)-dimethyl-3′-amino-3′-dA puromycin N-acetyltransferase Streptomyces Streptomyces - enzymology Streptomyces - genetics Streptomyces alboniger Streptomyces lividans Substrate Specificity
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