Robinson cytologic grading of invasive ductal breast carcinoma: Correlation with histologic grading and regional lymph node metastasis
To evaluate the importance of cytologic grading of breast carcinoma and its association with histologic grading and the existence of axillary lymph node metastasis. Aspirates and surgical samples from 100 patients with invasive ductal breast carcinoma not otherwise specified were studied. In 50 pati...
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| Veröffentlicht in: | Acta cytologica 2005-03, Vol.49 (2), p.149-153 |
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| creator | ROBLES-FRIAS, Antonio GONZALEZ-CAMPORA, Ricardo MARTINEZ-PARRA, Diego ROBLES-FRIAS, Maria José VAZQUEZ-CEREZUELA, Teresa OTAL-SALAVERRI, Conception FERNANDEZ-PALACINS, Ana |
| description | To evaluate the importance of cytologic grading of breast carcinoma and its association with histologic grading and the existence of axillary lymph node metastasis.
Aspirates and surgical samples from 100 patients with invasive ductal breast carcinoma not otherwise specified were studied. In 50 patients, > or = 1 metastatic nodes were identified. The cytologic grade was evaluated using the Robinson method and the histologic grade using the Elston modification of the Bloom-Richardson method. A study was undertaken to establish the association between histologic and cytologic grades and to compare the various parameters used to evaluate cytologic grade with the presence of axillary node metastasis.
A statistically significant association was observed between cytologic and histologic grades (p < 0.0005) and between cytologic grade and presence of axillary metastasis (p < 0.0005). Similarly, cell dissociation (p < 0.0005), cell uniformity (p = 0.0010) and the appearance of nuclear margins (p < 0.0005) all displayed a positive correlation with regional metastasis.
Cytologic grade may provide relevant information on the aggressiveness of invasive ductal breast carcinoma and could be a useful parameter to take into consideration when selecting neoadjuvant therapy. |
| doi_str_mv | 10.1159/000326123 |
| format | Article |
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Aspirates and surgical samples from 100 patients with invasive ductal breast carcinoma not otherwise specified were studied. In 50 patients, > or = 1 metastatic nodes were identified. The cytologic grade was evaluated using the Robinson method and the histologic grade using the Elston modification of the Bloom-Richardson method. A study was undertaken to establish the association between histologic and cytologic grades and to compare the various parameters used to evaluate cytologic grade with the presence of axillary node metastasis.
A statistically significant association was observed between cytologic and histologic grades (p < 0.0005) and between cytologic grade and presence of axillary metastasis (p < 0.0005). Similarly, cell dissociation (p < 0.0005), cell uniformity (p = 0.0010) and the appearance of nuclear margins (p < 0.0005) all displayed a positive correlation with regional metastasis.
Cytologic grade may provide relevant information on the aggressiveness of invasive ductal breast carcinoma and could be a useful parameter to take into consideration when selecting neoadjuvant therapy.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000326123</identifier><identifier>PMID: 15839618</identifier><identifier>CODEN: ACYTAN</identifier><language>eng</language><publisher>St. Louis, MO: Science Printers and Publishers</publisher><subject>Biological and medical sciences ; Biopsy, Fine-Needle - standards ; Biopsy, Fine-Needle - statistics & numerical data ; Breast Neoplasms - classification ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Carcinoma, Ductal - classification ; Carcinoma, Ductal - pathology ; Carcinoma, Ductal - therapy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymph Nodes - pathology ; Mammary gland diseases ; Mammary Glands, Human - pathology ; Medical sciences ; Neoplasm Invasiveness - pathology ; Pathology, Surgical - methods ; Pathology, Surgical - standards ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Tumors</subject><ispartof>Acta cytologica, 2005-03, Vol.49 (2), p.149-153</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16625955$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15839618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROBLES-FRIAS, Antonio</creatorcontrib><creatorcontrib>GONZALEZ-CAMPORA, Ricardo</creatorcontrib><creatorcontrib>MARTINEZ-PARRA, Diego</creatorcontrib><creatorcontrib>ROBLES-FRIAS, Maria José</creatorcontrib><creatorcontrib>VAZQUEZ-CEREZUELA, Teresa</creatorcontrib><creatorcontrib>OTAL-SALAVERRI, Conception</creatorcontrib><creatorcontrib>FERNANDEZ-PALACINS, Ana</creatorcontrib><title>Robinson cytologic grading of invasive ductal breast carcinoma: Correlation with histologic grading and regional lymph node metastasis</title><title>Acta cytologica</title><addtitle>Acta Cytol</addtitle><description>To evaluate the importance of cytologic grading of breast carcinoma and its association with histologic grading and the existence of axillary lymph node metastasis.
Aspirates and surgical samples from 100 patients with invasive ductal breast carcinoma not otherwise specified were studied. In 50 patients, > or = 1 metastatic nodes were identified. The cytologic grade was evaluated using the Robinson method and the histologic grade using the Elston modification of the Bloom-Richardson method. A study was undertaken to establish the association between histologic and cytologic grades and to compare the various parameters used to evaluate cytologic grade with the presence of axillary node metastasis.
A statistically significant association was observed between cytologic and histologic grades (p < 0.0005) and between cytologic grade and presence of axillary metastasis (p < 0.0005). Similarly, cell dissociation (p < 0.0005), cell uniformity (p = 0.0010) and the appearance of nuclear margins (p < 0.0005) all displayed a positive correlation with regional metastasis.
Cytologic grade may provide relevant information on the aggressiveness of invasive ductal breast carcinoma and could be a useful parameter to take into consideration when selecting neoadjuvant therapy.</description><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle - standards</subject><subject>Biopsy, Fine-Needle - statistics & numerical data</subject><subject>Breast Neoplasms - classification</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Carcinoma, Ductal - classification</subject><subject>Carcinoma, Ductal - pathology</subject><subject>Carcinoma, Ductal - therapy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymph Nodes - pathology</subject><subject>Mammary gland diseases</subject><subject>Mammary Glands, Human - pathology</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Pathology, Surgical - methods</subject><subject>Pathology, Surgical - standards</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M1qGzEQwHERWhLn45AXCLq0t0010kpa5VZMmwQCgdKczayktRV2JUdaJ_gF8twR1KXQ08Dw4z8whFwCuwaQ5htjTHAFXByRBRjRNVxJ9oks6h4aKVt9Qk5Lea5KKCWOyQnIThgF3YK8_0p9iCVFavdzGtM6WLrO6EJc0zTQEF-xhFdP3c7OONI-eywztZhtiGnCG7pMOfsR51ATb2He0E0o_4cwOpr9upKaGPfTdkNjcp5Ofq61eqCck88DjsVfHOYZefr54_fyrnl4vL1ffn9otlyYuTFcYus16s4MBloN0nEGQ6tboXqhOdgeEZnrmGPeMNUx3XNQfgDXAkAnzsjXP91tTi87X-bVFIr144jRp11ZKa1l17K2wqsD3PWTd6ttDhPm_erv5yr4cgBYLI5DxmhD-eeU4tJIKT4AiBd9uw</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>ROBLES-FRIAS, Antonio</creator><creator>GONZALEZ-CAMPORA, Ricardo</creator><creator>MARTINEZ-PARRA, Diego</creator><creator>ROBLES-FRIAS, Maria José</creator><creator>VAZQUEZ-CEREZUELA, Teresa</creator><creator>OTAL-SALAVERRI, Conception</creator><creator>FERNANDEZ-PALACINS, Ana</creator><general>Science Printers and Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Robinson cytologic grading of invasive ductal breast carcinoma: Correlation with histologic grading and regional lymph node metastasis</title><author>ROBLES-FRIAS, Antonio ; GONZALEZ-CAMPORA, Ricardo ; MARTINEZ-PARRA, Diego ; ROBLES-FRIAS, Maria José ; VAZQUEZ-CEREZUELA, Teresa ; OTAL-SALAVERRI, Conception ; FERNANDEZ-PALACINS, Ana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-925a4e7a789f914715d201f47436b3721cbaaa0d80d0e906807b216ef1d411183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle - standards</topic><topic>Biopsy, Fine-Needle - statistics & numerical data</topic><topic>Breast Neoplasms - classification</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Carcinoma, Ductal - classification</topic><topic>Carcinoma, Ductal - pathology</topic><topic>Carcinoma, Ductal - therapy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymph Nodes - pathology</topic><topic>Mammary gland diseases</topic><topic>Mammary Glands, Human - pathology</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Pathology, Surgical - methods</topic><topic>Pathology, Surgical - standards</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROBLES-FRIAS, Antonio</creatorcontrib><creatorcontrib>GONZALEZ-CAMPORA, Ricardo</creatorcontrib><creatorcontrib>MARTINEZ-PARRA, Diego</creatorcontrib><creatorcontrib>ROBLES-FRIAS, Maria José</creatorcontrib><creatorcontrib>VAZQUEZ-CEREZUELA, Teresa</creatorcontrib><creatorcontrib>OTAL-SALAVERRI, Conception</creatorcontrib><creatorcontrib>FERNANDEZ-PALACINS, Ana</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROBLES-FRIAS, Antonio</au><au>GONZALEZ-CAMPORA, Ricardo</au><au>MARTINEZ-PARRA, Diego</au><au>ROBLES-FRIAS, Maria José</au><au>VAZQUEZ-CEREZUELA, Teresa</au><au>OTAL-SALAVERRI, Conception</au><au>FERNANDEZ-PALACINS, Ana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Robinson cytologic grading of invasive ductal breast carcinoma: Correlation with histologic grading and regional lymph node metastasis</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytol</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>49</volume><issue>2</issue><spage>149</spage><epage>153</epage><pages>149-153</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><coden>ACYTAN</coden><abstract>To evaluate the importance of cytologic grading of breast carcinoma and its association with histologic grading and the existence of axillary lymph node metastasis.
Aspirates and surgical samples from 100 patients with invasive ductal breast carcinoma not otherwise specified were studied. In 50 patients, > or = 1 metastatic nodes were identified. The cytologic grade was evaluated using the Robinson method and the histologic grade using the Elston modification of the Bloom-Richardson method. A study was undertaken to establish the association between histologic and cytologic grades and to compare the various parameters used to evaluate cytologic grade with the presence of axillary node metastasis.
A statistically significant association was observed between cytologic and histologic grades (p < 0.0005) and between cytologic grade and presence of axillary metastasis (p < 0.0005). Similarly, cell dissociation (p < 0.0005), cell uniformity (p = 0.0010) and the appearance of nuclear margins (p < 0.0005) all displayed a positive correlation with regional metastasis.
Cytologic grade may provide relevant information on the aggressiveness of invasive ductal breast carcinoma and could be a useful parameter to take into consideration when selecting neoadjuvant therapy.</abstract><cop>St. Louis, MO</cop><pub>Science Printers and Publishers</pub><pmid>15839618</pmid><doi>10.1159/000326123</doi><tpages>5</tpages></addata></record> |
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| source | Karger Journals; MEDLINE |
| subjects | Biological and medical sciences Biopsy, Fine-Needle - standards Biopsy, Fine-Needle - statistics & numerical data Breast Neoplasms - classification Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma, Ductal - classification Carcinoma, Ductal - pathology Carcinoma, Ductal - therapy Female Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Lymph Nodes - pathology Mammary gland diseases Mammary Glands, Human - pathology Medical sciences Neoplasm Invasiveness - pathology Pathology, Surgical - methods Pathology, Surgical - standards Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Predictive Value of Tests Prognosis Retrospective Studies Tumors |
| title | Robinson cytologic grading of invasive ductal breast carcinoma: Correlation with histologic grading and regional lymph node metastasis |
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