Peptide induces CD4 +CD25 + and IL-10 + T cells and protection in airway allergy models

The purpose of this study was to evaluate whether a single peptide containing a major T cell epitope might induce peripheral tolerance in a complex allergen model. C57BL/6 mice were sensitized by intraperitoneal injection of house dust mite extract (HDM), and exposed to antigen via trachea instillat...

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Veröffentlicht in:	Vaccine 2005-05, Vol.23 (24), p.3181-3186
Hauptverfasser:	Zuleger, Cindy L., Gao, Xiaoyan, Burger, Melissa S., Chu, Qili, Payne, Lendon G., Chen, Dexiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Albumins - immunology Allergens - immunology Allergies Animals Applied microbiology Asthma Biological and medical sciences Bystander suppression CD4-Positive T-Lymphocytes - immunology Cell Proliferation Epitopes Female Fundamental and applied biological sciences. Psychology House dust House dust mite allergy Immunization Immunotherapy Interleukin-10 - metabolism Intravenous administration Laboratory animals Lymphocytes Mice Mice, Inbred C57BL Mice, Transgenic Microbiology Peptide vaccine Peptides Peripheral tolerance Pyroglyphidae - immunology Receptors, Interleukin-2 - immunology Regulatory T cells Respiratory Hypersensitivity - prevention & control Rodents Spleen - cytology Spleen - immunology Studies T-Lymphocytes - immunology T-Lymphocytes - metabolism Transgenic animals Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - therapeutic use
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