Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8+ T-cell responses to the tumor-specific antigen NY-ESO-1

Spontaneous immune responses to the cancer testis antigen NY-ESO-1 are frequently found in cancer patients bearing antigen-expressing tumors. In HLA-A2-expressing patients, naturally elicited NY-ESO-1-specific, tumor-reactive cytotoxic T lymphocytes (CTLs) are mostly directed against an immunodomina...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of immunotherapy (1997) 2005-05, Vol.28 (3), p.252-257
Hauptverfasser:	LE GAL, Frédérique-Anne, AYYOUB, Maha, DUTOIT, Valérie, WIDMER, Valérie, JÄGER, Elke, CEROTTINI, Jean-Charles, DIETRICH, Pierre-Yves, VALMORI, Danila
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Cancer Vaccines - immunology Humans Immunotherapy Medical sciences Molecular Sequence Data Neoplasm Proteins - immunology Peptide Fragments - immunology Pharmacology. Drug treatments Receptors, Antigen, T-Cell - chemistry T-Lymphocytes, Cytotoxic - immunology Vaccines, Subunit - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!