Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice

Human melanoma susceptibility is often characterized by germ-line inactivating CDKN2A (INK4A/ARF) mutations, or mutations that activate CDK4 by preventing its binding to and inhibition by INK4A. We have previously shown that a single neonatal UV radiation (UVR) dose delivered to mice that carry mela...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-03, Vol.66 (6), p.2946-2952
Hauptverfasser:	HACKER, Elke, MULLER, H. Konrad, WALKER, Graeme, IRWIN, Nicole, GABRIELLI, Brian, LINCOLN, Douglas, PAVEY, Sandra, POWELL, Marianne Broome, MALUMBRES, Marcos, BARBACID, Mariano, HAYWARD, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cocarcinogenesis Cyclin-Dependent Kinase 4 - genetics Dermatology Gene Expression Regulation, Neoplastic Genes, ras - genetics Genetic Predisposition to Disease Medical sciences Melanoma, Experimental - etiology Melanoma, Experimental - genetics Melanoma, Experimental - secondary Mice Mice, Transgenic Mutation Pharmacology. Drug treatments Tumors Tumors of the skin and soft tissue. Premalignant lesions Ultraviolet Rays
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